Association between circulating CTRP12 levels and type 2 diabetes: A meta-analysis

Table 1 Baseline characteristics of the included studies, mean ± SD

Ref.	Country	Study design	Age (years) T2DM/control	CTRP12/adipolin assay	Sample size (T2DM/control)	CTRP12 concentration (T2DM)	CTRP12 concentration (control)	Unit
Ameer et al[15], 2021	Iraq	Case-control study	35-60	ELISA	72 (54/18)	1.32 ± 0.48	1.64 ± 0.73	ng/mL
Bai et al[16], 2017	China	Cross-sectional study	51 ± 11.85/49 ± 11.11	ELISA	262 (124/138)	0.446.8 ± 87.92	808.5 ± 102.66	pg/mL
Liu et al[17], 2025	China	Case-control study	65.67 ± 3.29/66.02 ± 3.34	ELISA	278 (139/139)	2.7 ± 0.79	4.03 ± 1.14	ng/mL
Du et al[13], 2020	China	Case-control study	55.79 ± 10.06/49.32 ± 8.3	ELISA	169 (115/54)	424.14 ± 211.35	555.83 ± 244.23	pg/mL
Guo et al[18], 2021	China	Cross-sectional study	54.66 ± 9.61/52.73 ± 9.94	ELISA	231 (161/70)	2.36 ± 1.2	3.97 ± 1.22	ng/mL
Han et al[19], 2020	China	Case-control study	54 ± 7.42/51 ± 8.0	ELISA	83 (56/27)	392.3 ± 150.57	660.53 ± 160.51	pg/mL
Gorgani-Firuzjaee and Khodabandehloo[20], 2020	Iran	Case-control study	55.95 ± 1.97/46.44 ± 1.25	ELISA	60 (30/30)	167.36 ± 33	391.96 ± 91	pg/mL
Ligade et al[21], 2023	India	Cross-sectional study	20-50	ELISA	30 (20/10)	5.91 ± 4.36	7.68 ± 6.5	ng/mL
Yang et al[22], 2025	China	Case-control study	54.35 ± 8.07/54.54 ± 8.27	ELISA	196 (156/40)	2.68 ± 0.89	4.18 ± 1.14	ng/mL
Zhang and Huang[23], 2025	China	Case-control study	-	ELISA	250 (200/50)	2.17 ± 0.99	4.13 ± 1.25	ng/mL
Liu et al[24], 2025	China	Case-control study	-	ELISA	174 (116/58)	0.52 ± 0.13	0.91 ± 0.13	ng/mL
Sun et al[25], 2024	China	Case-control study	66.04 ± 3.91/66.11 ± 3.82	ELISA	298 (198/100)	478.58 ± 155.45	717.89 ± 244.4	pg/mL
Liu et al[26], 2019	China	Case-control study	47.29 ± 12.82/45.23 ± 13.23	ELISA	90 (60/30)	4.12 ± 1.45	6.84 ± 1.09	ng/mL

T2DM: Type 2 diabetes mellitus; CTRP12: C1q/TNF-related protein 12; ELISA: Enzyme-linked immunosorbent assay.