From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes

Figure 2 Activity profiles of short-acting insulin under different injection conditions. A: Different pharmacodynamic responses when short-acting insulin is injected into normal tissue, depot-affected tissue, or a ruptured depot site; B: Changes in blood glucose levels corresponding to injections at these different sites; C: Insulin concentration patterns in cases of mild depot formation, severe depot formation, and depot rupture.