Prediction model for rapid estimated glomerular filtration rate decline in type 2 diabetes mellitus

doi:10.4239/wjd.v17.i4.116772

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Apr 15, 2026; 17(4): 116772
Published online Apr 15, 2026. doi: 10.4239/wjd.v17.i4.116772

Table 2 Univariate analysis of risk factors for rapid estimated glomerular filtration rate decline, n (%)

Risk factors	Rapid decline (n = 89)	Non-rapid decline (n = 213)	χ² value	P value
Age
≥ 60 years	58 (65.2)	96 (45.1)	15.32	< 0.001
< 60 years	31 (34.8)	117 (54.9)	15.32	< 0.001
Diabetes duration
≥ 10 years	54 (60.7)	82 (38.5)	18.76	< 0.001
< 10 years	35 (39.3)	131 (61.5)	18.76	< 0.001
HbA1c control
≥ 8.0%	52 (58.4)	56 (26.3)	32.45	< 0.001
< 8.0%	37 (41.6)	157 (73.7)	32.45	< 0.001
Baseline eGFR
< 60 mL/minute/1.73 m²	64 (71.9)	72 (33.8)	41.28	< 0.001
≥ 60 mL/minute/1.73 m²	25 (28.1)	141 (66.2)	41.28	< 0.001
UACR
≥ 300 mg/g	58 (65.2)	48 (22.5)	52.36	< 0.001
< 300 mg/g	31 (34.8)	165 (77.5)	52.36	< 0.001
Systolic blood pressure
≥ 140 mmHg	58 (65.2)	84 (39.4)	22.15	< 0.001
< 140 mmHg	31 (34.8)	129 (60.6)	22.15	< 0.001
Diastolic blood pressure
≥ 90 mmHg	38 (42.7)	62 (29.1)	8.47	0.004
< 90 mmHg	51 (57.3)	151 (70.9)	8.47	0.004
Hyperuricemia
Yes	56 (62.9)	68 (31.9)	26.83	< 0.001
No	33 (37.1)	145 (68.1)	26.83	< 0.001
Anemia
Yes	62 (69.7)	68 (31.9)	31.54	< 0.001
No	27 (30.3)	145 (68.1)	31.54	< 0.001
Hypoalbuminemia
Yes	34 (38.2)	48 (22.5)	12.65	< 0.001
No	55 (61.8)	165 (77.5)	12.65	< 0.001
History of hypertension
Yes	72 (80.9)	142 (66.7)	9.82	0.002
No	17 (19.1)	71 (33.3)	9.82	0.002
History of coronary heart disease
Yes	28 (31.5)	42 (19.7)	7.31	0.007
No	61 (68.5)	171 (80.3)	7.31	0.007
RAAS inhibitor use
Non-use	42 (47.2)	60 (28.2)	11.73	0.001
Use	47 (52.8)	153 (71.8)	11.73	0.001
SGLT-2 inhibitor use
Non-use	61 (68.5)	110 (51.6)	8.95	0.003
Use	28 (31.5)	103 (48.4)	8.95	0.003

Hyperuricemia: Serum uric acid ≥ 420 μmol/L (males) or ≥ 360 μmol/L (females); anemia: Hemoglobin < 130 g/L (males) or < 120 g/L (females). HbA1c: Hemoglobin A1c; eGFR: Estimated glomerular filtration rate; UACR: Urine albumin-to-creatinine ratio; RAAS: Renin-angiotensin-aldosterone system; SGLT-2: Sodium-glucose cotransporter-2.

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Citation: Huang P, Qin XQ, Huang Q, Wang SD, Wu YY, Huang XR, Lin X. Prediction model for rapid estimated glomerular filtration rate decline in type 2 diabetes mellitus. World J Diabetes 2026; 17(4): 116772
URL: https://www.wjgnet.com/1948-9358/full/v17/i4/116772.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i4.116772

Huang P, Qin XQ, Huang Q, Wang SD, Wu YY, Huang XR, Lin X. Prediction model for rapid estimated glomerular filtration rate decline in type 2 diabetes mellitus. World J Diabetes 2026; 17(4): 116772 [DOI: 10.4239/wjd.v17.i4.116772]

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