Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNAThr/tRNAPro mutation

Table 4 Summary of clinical and molecular data for several Chinese diabetic pedigrees carrying the primary mitochondrial-transfer RNA mutations

Pedigree number	Number of matrilineal relatives	Penetrance of diabetes (%)	mt-tRNA mutations	mtDNA haplogroup	Ref.
1	12	50	tRNAThr/tRNAPro C14954T	F1b1a1	This study
2	11	45.4	tRNAGlu A14687G	G4	Levinger et al[51]
3	11	18.2	tRNAGlu A14692G	B5	Moslemi et al[52]
4	12	41.6	tRNACys/tRNATyr A5826G	D4	Roe et al[41]
5	12	25	tRNALeu(UUR) A3243G	M7c	Jiang et al[17]
6	8	50	tRNAAla T5587C	F2	Brandon et al[15]
7	19	31.5	tRNATrp A5514G	G2a	Crispim et al[53]
8	19	26.3	tRNAThr G15897A	D4b1	Achilli et al[54]
9	11	45.5	tRNAGly T10003C	M11b	Fang et al[55]

mt: Mitochondrial; tRNA: Transfer RNA.