Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNAThr/tRNAPro mutation

doi:10.4239/wjd.v17.i4.115842

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Apr 15, 2026; 17(4): 115842
Published online Apr 15, 2026. doi: 10.4239/wjd.v17.i4.115842

Table 2 Mitochondrial DNA variants in matrilineal relatives of this type 2 diabetes mellitus pedigree

Gene	Position	Alterations	Amino acid changes	rCRS	Conservation (H/B/M/X)	Reported¹
D-loop	73	A to G		A		Yes
	263	A to G		A		Yes
	310	Ins C		T		Yes
	16132	T to C		T		Yes
	16224	T to C		T		Yes
12S rRNA	750	A to G		A	A/A/A/-	Yes
	1107	T to C		T	T/C/T/T	Yes
	1438	A to G		A	A/A/A/G	Yes
16S rRNA	2706	A to G		A	A/G/A/A	Yes
	3107	del N		N	N/T/T/-	Yes
ND1	4200	A to T		A		Yes
	4216	T to C	Tyr to His	T	Y/Y/H/H	Yes
ND2	5178	C to A	Leu to Met	C	L/T/T/T	Yes
CO1	7028	C to T		C		Yes
A6	8414	C to T	Leu to Phe	C	L/F/M/W	Yes
	8584	G to A	Ala to Thr	G	A/V/V/I	Yes
	8701	A to G	Thr to Ala	A	T/S/L/Q	Yes
	8860	A to G	Thr to Ala	A	T/A/A/T	Yes
CO3	9540	T to C		T		Yes
	9545	A to G		A		Yes
ND3	10397	A to G		A		Yes
	10398	A to G	Thr to Ala	A	T/T/T/A	Yes
	10400	C to T		C		Yes
ND4	11722	G to A		G		Yes
	11917	G to A		G		Yes
ND5	12705	C to T		C		Yes
ND6	14318	T to C		T		Yes
	14766	C to T	Thr to Ile	C	T/S/T/S	Yes
CytB	14927	A to G		A		Yes
	15043	G to A		G		Yes
	15301	G to A		G		Yes
	15326	A to G	Thr to Ala	A	T/M/I/I	Yes
tRNA^Thr/tRNA^Pro	15954	C to T		C	C/C/C/C	No

¹Please see online MITOMAP (http://www.MITOMAP.org), mtDB (http://www.genpat.uu.se/mtDB) databases.

rCRS: Reversed Cambridge reference sequences; H: Human; B: Bovine; M: Mouse; X: Xenopus laevis; Tyr: Tyrosine; His: Histidine; Leu: Leucine; Met: Methionine; Phe: Phenylalanine; Ala: Alanine; Thr: Threonine; Ile: Isoleucine.

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Citation: Xu L, Liu MT, He XM, Zhang SR, Yu DJ, Ding Y. Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNA^Thr/tRNA^Pro mutation. World J Diabetes 2026; 17(4): 115842
URL: https://www.wjgnet.com/1948-9358/full/v17/i4/115842.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i4.115842

Xu L, Liu MT, He XM, Zhang SR, Yu DJ, Ding Y. Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNA^Thr/tRNA^Pro mutation. World J Diabetes 2026; 17(4): 115842 [DOI: 10.4239/wjd.v17.i4.115842]

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