Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNAThr/tRNAPro mutation

Table 1 Summary of clinical and biochemical data of several matrilineal relatives in this pedigree with type 2 diabetes mellitus

Subjects	Gender	BMI (kg/m2)	Age at onset (year)	Age at test (year)	HbA1c (%)	Glucose (0-hour, mmol/L)	Glucose (2-hour, mmol/L)	Fast insulin (mU/L)	HOMA-IR	TG (mmol/L)	TC (mmol/L)	Serum Cr (μmol/L)	mAlb (mg/L)	α1-mG (mg/L)	eGFR (mL/minute)	BP (mmHg)
II-4	F	23.0	66	72	6.9	7.3	12.6	14.2	4.61	1.22	4.71	122.0	977.2	39.7	69	145/90
II-6	F	22.2	59	63	7.2	7.9	13.5	11.66	4.11	1.09	3.30	139.0	1055.6	47.3	53	155/75
III-4	F	26.2	42	44	6.6	8.8	11.9	7.10	2.79	3.20	5.90	88.0	10.9	9.4	100	155/80
III-10	F	24.3	41	46	6.5	7.2	12.0	6.6	2.11	2.60	2.99	59.0	7.7	8.05	88	140/70
III-9	M	20.5		39	5.2	4.8	7.8	4.2	0.89	1.30	3.48	77.0	6.3	11.1	119	125/75
Normal range		20-22			4.0-6.1	3.9-6.1	3.9-7.8	2.6-12.0	< 2.5	< 1.7	< 5.69	41-81	0-19	0-12.5	80-130	< 140/90

BMI: Body mass index; HbA1c: Glycosylated hemoglobin; HOMA-IR: Homeostatic model assessment for insulin resistance; TG: Triglycerides; TC: Total cholesterol; Cr: Creatinine; mAlb: Microalbumin; α1-mG: Α1-microglobulin; eGFR: Estimated glomerular filtration rate; BP: Blood pressure; F: Female; M: Male.