EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression

doi:10.4239/wjd.v17.i4.115437

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Apr 15, 2026; 17(4): 115437
Published online Apr 15, 2026. doi: 10.4239/wjd.v17.i4.115437

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Figure 7 Inhibition of the EP300-nephrocystin-4 axis affects renal fibrosis markers in diabetic nephropathy mice. A: Measurement of nephrocystin-4 protein levels by immunohistochemistry. Scale bar = 100 µm; B: Measurement of alpha-smooth muscle actin protein levels by immunofluorescence. Scale bar = 50 µm; C: Measurement of fibronectin protein levels by immunofluorescence. Scale bar = 50 µm. α-SMA: Alpha-smooth muscle actin; HFD: High-fat diet; STZ: Streptozotocin.

Citation: Si W, Dai Y, Hu GP, Zhang Q, Lv F, Zhang Q. EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression. World J Diabetes 2026; 17(4): 115437
URL: https://www.wjgnet.com/1948-9358/full/v17/i4/115437.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i4.115437

Si W, Dai Y, Hu GP, Zhang Q, Lv F, Zhang Q. EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression. World J Diabetes 2026; 17(4): 115437 [DOI: 10.4239/wjd.v17.i4.115437]

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