EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression

Figure 1 Transcriptome screening of candidate genes. A: Three-dimensional principal component analysis ; B: Variance analysis volcano map; C: Venny plots of candidate genes; D: Penalty plot of least absolute shrinkage and selection operator logistic regression coefficients; E: Least absolute shrinkage and selection operator cross validation diagram; F: Potential biomarkers screened by machine learning-support vector machine-recursive feature elimination algorithm; G: Machine learning intersection genes; H: GSEA enrichment results for key genes; I: Box plot of key gene expression. ^bP < 0.01, ^cP < 0.001. DEGs: Differentially expressed genes; DN: Diabetic nephropathy.