SLC30A8 promoter hypermethylation is associated with type 2 diabetes and diabetic kidney disease in a Chinese population

Figure 3 DNA methylation changes of solute carrier family 30 member 8 in kidneys of db/db mice and pancreatic tissues of serous cystadenoma patients. A: Solute carrier family 30 member 8 (SLC30A8) is expressed in the proximal convoluted tubule and collecting duct principal cells of kidneys, which is predicted by single cell-RNA sequencing analysis. B and C: SLC30A8 DNA methylation and RNA expression levels in whole kidney of db/db mice with diabetic kidney disease and without diabetic kidney disease; D: SLC30A8 promoter hypermethylation exists in pancreatic tissue of pancreatic serous cystadenoma patients with and without type 2 diabetes; E: SLC30A8 promoter DNA methylation levels in physical exercise intervention program in the youth subjects are not influenced by physical activity from the baseline to 3-months follow-up. SLC30A8: Solute carrier family 30 member 8; CON: Control, db/db mice without diabetic kidney disease; DKD: Diabetic kidney disease; PiPy: Physical exercise intervention program in the youth; T2D: Type 2 diabetes; SCA: Pancreatic serous cystadenoma.