SLC30A8 promoter hypermethylation is associated with type 2 diabetes and diabetic kidney disease in a Chinese population

doi:10.4239/wjd.v17.i3.113947

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Mar 15, 2026; 17(3): 113947
Published online Mar 15, 2026. doi: 10.4239/wjd.v17.i3.113947

Table 1 Clinical parameters of non-diabetic control subjects, type 2 diabetes and diabetic kidney disease patients, mean ± SD

	NDC	Newly T2D	T2D	DKD	P value, a/b/c
N (females)	132 (43.2%)	135 (43.0%)	399 (41.1%)	154 (35.1%)
Age (years)	55 ± 17	52 ± 14	55 ± 16	60 ± 14	0.548/0.192/0.005
BMI (kg/m²)	25.2 ± 5.2	25.1 ± 4.1	25.5 ± 3.7	25.6 ± 3.7	0.994/0.725/0.995
SBP (mmHg)	135 ± 18	130 ± 16	135 ± 18	141 ± 20	0.029/0.047/0.001
DBP (mmHg)	85 ± 15	83 ± 9	82 ± 11	81 ± 13	0.729/0.812/0.649
FBG (mol/L)	5.6 ± 1.9	9.2 ± 4.1	8.0 ± 3.3	8.1 ± 3.7	< 0.001/0.002/0.992
HbA1c (%)/(mmol/mol)¹	6.0 ± 1.5/42.4 ± 16.1	10.1 ± 2.7/86.5 ± 26.3	8.8 ± 2.2/72.7 ± 23.9	9.2 ± 2.1/77.1 ± 23.0	< 0.001/< 0.001/0.204
Fc-peptide (ng/mL)	1.94 ± 1.34	1.59 ± 0.97	1.83 ± 1.08	2.04 ± 1.65	0.124/0.245/0.266
UACR (mg/g)	8.6 ± 11.5	11.7 ± 12.9	142.5 ± 51.6	914.3 ± 346.7	0.996/0.214/< 0.001
SCr (μmol/L)	70.2 ± 25.3	63.0 ± 15.2	72.5 ± 25.4	120.1 ± 106.2	0.650/0.235/< 0.001
BUN (mmol/L)	7.9 ± 3.1	5.4 ± 1.6	6.8 ± 6.8	9.6 ± 14.3	0.146/0.492/0.016
LDL (mmol/L)	2.6 ± 0.6	3.1 ± 0.9	2.8 ± 0.9	2.8 ± 1.0	< 0.001/0.027/0.995
HDL (mmol/L)	1.3 ± 0.3	3.5 ± 0.8	1.3 ± 0.3	1.3 ± 0.3	0.063/0.014/0.996
TG (mmol/L)	1.7 ± 1.2	2.0 ± 1.7	2.2 ± 2.7	2.2 ± 2.3	0.708/0.936/0.992
TC (mmol/L)	4.4 ± 0.9	4.9 ± 1.3	4.7 ± 1.3	4.8 ± 1.3	0.004/0.298/0.959
AST (U/L)	21.8 ± 14.8	19.5 ± 16.5	20.6 ± 18.5	19.3 ± 13.7	0.649/0.897/0.825
ALT (U/L)	31.3 ± 32.2	26.6 ± 22.9	24.9 ± 31.7	20.8 ± 14.7	0.528/0.935/0.431

¹Converted with National Glycohemoglobin Standardization Program to International Federation of Clinical Chemistry unit: Mmol/mol; P values, a: Non-diabetic control subjects vs newly diagnosed type 2 diabetes; b: Newly diagnosed type 2 diabetes vs type 2 diabetes; c: Type 2 diabetes vs diabetic kidney disease.

NDC: Non-diabetic control subjects; Newly T2D: Newly diagnosed type 2 diabetes; T2D: Type 2 diabetes; DKD: Diabetic kidney disease; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FBG: Fasting blood glucose; HbA1c: Glycated hemoglobin; UACR: Urinary albumin-to-creatinine ratio; SCr: Serum creatinine; BUN: Serum urea nitrogen; HDL: High density lipoprotein-cholesterol; LDL: Low density lipoprotein-cholesterol; TG: Triglyceride; TC: Total cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.

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Citation: Li N, Li YP, Xu Q, Xu J, Yu YH, Su J, Shen C, Yu JY, Gu HF. SLC30A8 promoter hypermethylation is associated with type 2 diabetes and diabetic kidney disease in a Chinese population. World J Diabetes 2026; 17(3): 113947
URL: https://www.wjgnet.com/1948-9358/full/v17/i3/113947.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i3.113947

Li N, Li YP, Xu Q, Xu J, Yu YH, Su J, Shen C, Yu JY, Gu HF. SLC30A8 promoter hypermethylation is associated with type 2 diabetes and diabetic kidney disease in a Chinese population. World J Diabetes 2026; 17(3): 113947 [DOI: 10.4239/wjd.v17.i3.113947]

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