Amomum villosum extract alleviates diabetic neuropathy via phosphoinositide 3-kinase/AKT-mediated antioxidative and anti-apoptotic effects

Figure 1 Amomum villosum Lour. treatment counteracted hyperglycemia and weight loss in diabetic rats. A type 1 diabetic rat model was established by intraperitoneal injection of 60 mg/kg streptozotocin for seven consecutive days in week 1, and the control group was injected with an equal volume of sterile saline. Starting from week 2, Amomum villosum Lour. (AVL) was administered intraperitoneally once daily until the end of the experiment. The total study duration was 5 weeks. Blood glucose and body weight were recorded regularly. A: Blood glucose level; B: Rat body weight. ^aP < 0.05 diabetes mellitus (DM) + vehicle group vs control group.