Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model

Figure 8 Effect of polyherbal extract treatment on the pancreas section. A: Control. The sections showed normal histological attributes of the pancreatic tissue. The islets of Langerhans appeared normal, with no evidence of cellular disintegration, pyknosis or atrophic changes in the beta cells (indicated by the green arrow). In addition, normal pyramidal acidophilic pancreatic acini were seen (yellow arrow). No congestion or haemorrhage was found; B: Diabetic. The sections showed significantly distorted pancreatic lobules and cellular disintegration in the islets of Langerhans (orange arrow), along with haemorrhage (green arrow). Marked pyknosis was seen in the beta cells (yellow arrow). Pancreatic acini were atrophic and significantly disintegrated (blue arrow) and fibrotic (black arrow); C: Diabetic + polyherbal extract. The sections showed moderately damaged pancreatic lobules and cellular disintegration in the islets of Langerhans (orange arrow). Healthy beta cells were represented by the green arrow. Mild pyknosis was seen in the beta cells (black arrow). No congestion or haemorrhage was found; D: Diabetic + metformin. The sections showed mild to moderate damaged pancreatic lobules and cellular disintegration in the islets of Langerhans (orange arrow). Healthy beta cells were represented by the green arrow. Moderate pyknosis was observed in the beta cells (indicated by the black arrow). No congestion or haemorrhage was found; E: Polyherbal extract. The sections showed normal histological attributes of the pancreatic tissue. The islets of Langerhans appeared normal, with no evidence of cellular disintegration, pyknosis or atrophic changes in the beta cells (green arrow). Moreover, normal pyramidal acidophilic pancreatic acini were seen (yellow arrow). No congestion or haemorrhage was found (magnification 400 ×; scale bar 50 μm).