Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model

Figure 6 Effects of polyherbal extract on the protein expression of the neuron-specific markers in the serum and sciatic nerve tissue. A: Brain-derived neurotrophic factor; B: Nerve growth factor. The diabetic group experienced a significant reduction in the levels of brain-derived neurotrophic factor and nerve growth factor compared with the control group. However, the administration of polyherbal extract significantly ameliorated their levels in the diabetic + polyherbal extract group compared with the diabetic group. Data are expressed as mean ± SEM (n = 7). ^aP < 0.05 vs control group, ^bP < 0.01 vs control group, ^cP < 0.001 vs control group, ^dP < 0.05 vs diabetic group, ^eP < 0.01 vs diabetic group. Met: Metformin; PHE: Polyherbal extract; BDNF: Brain-derived neurotrophic factor; NGF: Nerve growth factor.