Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model

Table 2 The effect of polyherbal extract treatment on blood glucose, insulin and haemoglobin level of control and experimental groups, mean ± SEM

Groups1	Blood glucose (mg/dL)	Insulin (ng/mL)	Haemoglobin (%)
Control	96.4 ± 3.6	3.8 ± 0.65	4.9 ± 0.61
Diabetic	284.4 ± 5.1a (+195.02%)	0.68 ± 0.36a (-82.11%)	7.9 ± 0.52a (+61.22%)
Diabetic + PHE	198.6 ± 4.9d (-30.17%)	2.8 ± 0.46d (+311.76%)	6.4 ± 0.71d (-18.99%)
Diabetic + Met	168.3 ± 4.1d (-40.82%)	3.1 ± 0.69d (+355.88%)	5.9 ± 0.41d (-25.32%)
Control + PHE	119.5 ± 4.6 (+23.96%)	3.4 ± 0.67 (-10.53 %)	5.1 ± 0.56 (+4.08%)

¹The diabetic group showed a significant increase in fasting blood glucose and glycosylated haemoglobin with a significant decrease in insulin compared with the control group. Polyherbal extract treatment significantly augmented these parameters in the diabetic + polyherbal extract group compared with the diabetic group. Values in parentheses indicate percentage increase (+) or decrease (-) as compared with the control or the diabetic group.

^aP < 0.05 vs control group.

^dP < 0.05 vs diabetic group.

PHE: Polyherbal extract; Met: Metformin.