Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model

doi:10.4239/wjd.v17.i2.113992

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2026; 17(2): 113992
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.113992

Table 1 The effect of polyherbal extract treatment on body weight of control and experimental groups, mean ± SEM

Groups	Body weight¹ (g)
Groups	Week 0	Week 8
Control	195.4 ± 6.0	245.3 ± 7.7 (-3.70%)
Diabetic	185.6 ± 5.2 (-5.02%)	155.6 ± 6.5^a (-36.57%)
Diabetic + PHE	188.4 ± 5.8 (+1.51%)	220.7 ± 7.4^d (+41.84%)
Diabetic + Met	198.7 ± 4.5 (+7.06%)	210.5 ± 5.8^d (+35.28%)
Control + PHE	189.7 ± 5.6 (-2.92 %)	238.6 ± 6.9 (-2.73%)

¹The diabetic groups treated with polyherbal extract or metformin showed increased in body weight compared to the untreated diabetic group. Values in parentheses indicate percentage increase (+) or decrease (-) as compared with the control or the diabetic group.

^aP < 0.05 vs the control group.

^dP < 0.05 vs diabetic group.

PHE: Polyherbal extract; Met: Metformin.

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Citation: Kausar MA, Parveen K, Anwar S, Khan YS, Saleh AA, Ahmed MAA, Siddiqui WA, Parvez S. Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model. World J Diabetes 2026; 17(2): 113992
URL: https://www.wjgnet.com/1948-9358/full/v17/i2/113992.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i2.113992

Kausar MA, Parveen K, Anwar S, Khan YS, Saleh AA, Ahmed MAA, Siddiqui WA, Parvez S. Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model. World J Diabetes 2026; 17(2): 113992 [PMID: 41696095 DOI: 10.4239/wjd.v17.i2.113992]

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