Association of serum bile acid profiles with the risk of gastrointestinal autonomic neuropathy in patients with type 2 diabetes mellitus

Table 3 Univariate logistic regression analysis of clinical indicators and bile acids in the type 2 diabetes mellitus and diabetic gastric autonomic neuropathy groups

Variables	Univariate logistic regression analysis
	OR (95%CI)	P value
Clinical indicators
Gender, F, %	1.131 (0.436-2.935)	0.800
Age, years	0.941 (0.904-0.978)	0.002b
BMI, kg/m2	0.759 (0.635-0.907)	0.002b
Duration of diabetes, months	1.002 (0.997-1.008)	0.388
SBP, mmHg	0.999 (0.973-1.025)	0.929
DBP, mmHg	1.029 (0.988-1.071)	0.172
WBC, × 109/L	0.855 (0.650-1.123)	0.260
Hb, g/L	0.962 (0.936-0.989)	0.006b
PLT, × 109/L	1.000 (0.992-1.008)	0.995
CRP, mg/L	1.068 (0.987-1.157)	0.103
FBG, mmol/L	0.874 (0.732-1.044)	0.137
HbA1c, %	0.895 (0.720-1.113)	0.320
FC-P, nmol/L	0.062 (0.011-0.339)	0.001b
2hC-P, nmol/L	0.185 (0.078-0.438)	< 0.001b
BUN, mmol/L	0.873 (0.683-1.117)	0.281
SCr, µmol/L	1.004 (0.991-1.017)	0.555
eGFR, mL/min/1.73 m2	1.013 (0.990-1.036)	0.264
UACR, mg/g	1.001 (1.000-1.003)	0.037a
TG, mmol/L	0.551 (0.327-1.929)	0.065
TC, mmol/L	0.985 (0.677-1.433)	0.937
LDL-C, mmol/L	0.864 (0.540-1.382)	0.542
HDL-C, mmol/L	0.393 (0.052-2.972)	0.365
ALB, g/L	0.895 (0.808-0.992)	0.034a
ALT, U/L	0.960 (0.916-1.006)	0.088
AST, U/L	0.948 (0.887-1.012)	0.111
BAs characteristics
CA, nmol/L	1.001 (1.000-1.002)	0.070
DCA, nmol/L	1.000 (0.999-1.001)	0.813
CDCA, nmol/L	1.000 (1.000-1.001)	0.386
UDCA, nmol/L	0.997 (0.993-1.001)	0.169
LCA, nmol/L	0.996 (0.979-1.014)	0.673
GCA, nmol/L	1.000 (1.000-1.001)	0.276
GLCA, nmol/L	0.948 (0.886-1.014)	0.120
GDCA, nmol/L	1.000 (0.999-1.001)	0.663
GCDCA, nmol/L	1.000 (1.000-1.000)	0.832
GUDCA, nmol/L	0.999 (0.996-1.002)	0.561
TCA, nmol/L	1.003 (0.998-1.007)	0.226
TLCA, nmol/L	0.603 (0.377-0.964)	0.035a
TDCA, nmol/L	0.985 (0.968-1.003)	0.106
TCDCA, nmol/L	1.001 (0.999-1.003)	0.201
TUDCA, nmol/L	1.014 (0.986-1.043)	0.333

^aP < 0.05.

^bP < 0.01.

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; Hb: Hemoglobin; PLT: Platelets; CRP: C-reactive protein; FBG: Fasting blood glucose; HbA1c: Hemoglobin a1c; FC-P: Fasting C-peptide; 2hC-P: 2-hour C-peptide; BUN: Blood urea nitrogen; SCr: Serum creatinine; eGFR: Estimated glomerular filtration rate; UACR: Urinary albumin-to-creatinine ratio; TG: Triglycerides; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CA: Cholic acid; DCA: Deoxycholic acid; CDCA: Chenodeoxycholic acid; UDCA: Ursodeoxycholic acid; LCA: Lithocholic acid; GCA: Glycocholic acid; GLCA: Glycolithocholic acid; GDCA: Glycodeoxycholic acid; GCDCA: Glycochenodeoxycholic acid; GUDCA: Glycoursodeoxycholic acid; TCA: Taurocholic acid; TLCA: Taurolithocholic acid; TDCA: Taurodeoxycholic acid; TCDCA: Taurochenodeoxycholic acid; TUDCA: Tauroursodeoxycholic acid; OR: Odds ratios; CI: Confidence interval; F: Female; BA: Bile acid.