Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney

Figure 4 Fibroblast growth factor 1 regulates the expression of genes involved in fatty acid metabolism in diabetic nephropathy. A: The mRNA expression levels of carnitine palmitoyl transferase 1A (CPT1a) and peroxisome proliferator-activated receptor alpha (PPARα) detected by RT-qPCR; B: Western blot analysis of cluster of differentiation 36, CPT1a, PPARα, and P-AMP-activated protein kinase in diabetic nephropathy; C-F: Quantification of protein expression levels of cluster of differentiation 36, CPT1a, PPARα, and AMP-activated protein kinase phosphorylation. Data were presented as mean ± SD. ^aP < 0.05. AMPK: AMP-activated protein kinase; CD36: Cluster of differentiation 36; CPT1a: Carnitine palmitoyl transferase 1A; Ctrl: Control; FGF1: Fibroblast growth factor 1; PPARα: Peroxisome proliferator-activated receptor alpha; T2DM: Type 2 diabetes mellitus.