Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder

doi:10.4239/wjd.v17.i2.111453

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2026; 17(2): 111453
Published online Feb 15, 2026. doi: 10.4239/wjd.v17.i2.111453

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Figure 2 Jiangtang Tiaozhi formula modulates liver transcriptome profiles. A: Principal components analysis [control vs model vs Jiangtang Tiaozhi formula (JTTZF) mice, n = 8]; B: Volcano plots (model vs control mice, n = 8); C: Volcano plots (JTTZF vs model mice, n = 8); D: Heatmap of representative differentially expressed genes (control vs model vs JTTZF mice, n = 8), with red indicating up-regulation and blue indicating down-regulation; E: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to annotate the biological function of differential genes(model vs control mice, n = 8); F: KEGG pathway analysis to annotate the biological function of differential genes (JTTZF vs model mice, n = 8). JTTZF: Jiangtang Tiaozhi formula; PC: Principal component.

Citation: Tian JX, Zhang YJ, Zhang YX, Wei JH, Fang XY, Miao RY, Ma KL, Guan HF, Wang XM, Wu HR. Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder. World J Diabetes 2026; 17(2): 111453
URL: https://www.wjgnet.com/1948-9358/full/v17/i2/111453.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i2.111453

Tian JX, Zhang YJ, Zhang YX, Wei JH, Fang XY, Miao RY, Ma KL, Guan HF, Wang XM, Wu HR. Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder. World J Diabetes 2026; 17(2): 111453 [PMID: 41696100 DOI: 10.4239/wjd.v17.i2.111453]

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