Cluster analysis of computed tomography identifies duration-associated abdominal fat deposition in type 2 diabetes mellitus

doi:10.4239/wjd.124565

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Nov 15, 2026; 17(11): 124565
Published online Nov 15, 2026. doi: 10.4239/wjd.124565

Table 3 Comparison of fasting plasma glucose, 2-hour oral glucose tolerance test, and glycated hemoglobin among different groups and multiple linear regression analysis

Item	FPG	2 hours OGTT	HbA1c
Item	β (SE, P value)	β (SE, P value)	β (SE, P value)
Prediabetes group
liver (HU)	-0.179 (0.158, 0.049)^a	-0.204 (0.288, 0.045)^a	-0.404 (0.011, 0.118)
Pancreas (HU)	-0.077 (0.023, 0.671)	-0.461 (0.047, 0.121)	-0.204 (0.019, 0.056)
DMa group
liver (HU)	-0.445 (0.611, 0.017)^a	-0.401 (0.117, 0.040)^a	-0.340 (0.419, 0.047)^a
Pancreas (HU)	-0.420 (0.088, 0.032)^a	-0.268 (0.216, 0.034)^a	-0.205 (0.069, 0.038)^a
VAT (mm²)	0.079 (0.006, 0.137)	0.016 (0.012, 0.117)	0.044 (0.004, 0.136)
SAT (mm²)	0.161 (0.004, 0.067)	0.110 (0.008, 0.074)	0.143 (0.002, 0.110)
DMb group
liver (HU)	-0.025 (0.666, 0.048)^a	-0.439 (0.008, 0.044)^a	-0.180 (0.004, 0.014)^a
Pancreas (HU)	-0.182 (0.109, 0.037)^a	-0.317 (0.091, 0.014)^a	-0.230 (0.050, 0.022)^a
Psoas major (HU)	-0.153 (0.053, 0.026)^a	-0.192 (0.077, 0.016)^a	-0.017 (0.035, 0.890)
Renal parenchyma (HU)	-0.260 (0.112, 0.009)^a	-0.588 (0.194, 0.029)^a	-0.022 (0.077, 0.048)^a
Renal sinus fat area (mm²)	0.273 (0.419, 0.028)^a	0.381 (0.084, 0.038)^a	0.285 (0.280, 0.007)^a

^aP < 0.05.

Β: Standardized coefficient; SE: Standard error; DMa: Type 2 diabetes mellitus with disease duration < 5 years; DMb: Type 2 diabetes mellitus with disease duration ≥ 5 years; BMI: Body mass index; FPG: Fasting plasma glucose; OGTT: Oral glucose tolerance test; HbA1c: Glycated hemoglobin; Scr: Serum creatinine; BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; TG: Triglyceride; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Yang FZ, Li HY, Li G, Zhang YL, Ji Q. Cluster analysis of computed tomography identifies duration-associated abdominal fat deposition in type 2 diabetes mellitus. World J Diabetes 2026; 17(11): 124565
URL: https://www.wjgnet.com/1948-9358/full/v17/i11/124565.htm
DOI: https://dx.doi.org/10.4239/wjd.124565

Yang FZ, Li HY, Li G, Zhang YL, Ji Q. Cluster analysis of computed tomography identifies duration-associated abdominal fat deposition in type 2 diabetes mellitus. World J Diabetes 2026; 17(11): 124565 [DOI: 10.4239/wjd.124565]

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