Diabetes as a pan-cancer risk factor: Triangulated evidence from global burden, longitudinal cohorts, and Mendelian randomization

doi:10.4239/wjd.124123

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Nov 15, 2026; 17(11): 124123
Published online Nov 15, 2026. doi: 10.4239/wjd.124123

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Figure 3 Nonlinear relationships of diabetes-related markers and cancer prevalence. A: Nonlinear relationships of diabetes duration and cancer prevalence in the National Health and Nutrition Examination Survey; B: Nonlinear relationships of triglyceride-glucose index and cancer prevalence in the China Health and Retirement Longitudinal Study; C: Nonlinear relationships of metabolic score for insulin resistance and cancer prevalence in the China Health and Retirement Longitudinal Study. OR: Odds ratio; TyG: Triglyceride-glucose; METS-IR: Metabolic score for insulin resistance.

Citation: Lu Y, Chai MS, Lan QY, Yang QM, Yang FR, Xiao TN, Kong XW, Zhou PR, Hua H. Diabetes as a pan-cancer risk factor: Triangulated evidence from global burden, longitudinal cohorts, and Mendelian randomization. World J Diabetes 2026; 17(11): 124123
URL: https://www.wjgnet.com/1948-9358/full/v17/i11/124123.htm
DOI: https://dx.doi.org/10.4239/wjd.124123

Lu Y, Chai MS, Lan QY, Yang QM, Yang FR, Xiao TN, Kong XW, Zhou PR, Hua H. Diabetes as a pan-cancer risk factor: Triangulated evidence from global burden, longitudinal cohorts, and Mendelian randomization. World J Diabetes 2026; 17(11): 124123 [DOI: 10.4239/wjd.124123]

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