Cluster-based metabolic subphenotypes and projected cross-organ risk in Chinese adults with prediabetes

Figure 2 Within-subtype prevalence and source contribution of threshold-defined intermediate/high-risk status across metabolic subtypes. A: It shows the percentage of participants within each metabolic subtype who met the primary analytic threshold for each risk-score-derived measure; B: It shows the proportion of all threshold-positive participants accounted for by each subtype for the same measure. Primary analytic thresholds were defined as Framingham-estimated 10-year cardiovascular disease risk ≥ 10%, chronic kidney disease (CKD) prognosis consortium-estimated projected 5-year CKD risk ≥ 5%, and fibrosis-4 (FIB-4) index ≥ 1.30. The corresponding threshold-positive counts were 131 of 452 participants for cardiovascular disease risk, 117 of 448 participants for projected CKD risk, and 152 of 621 participants for FIB-4. Percentages are rounded to one decimal place and may not sum exactly to 100.0%. These categories represent score-defined intermediate/high-risk status and FIB-4-defined liver fibrosis-risk signal, not observed incident cardiovascular, kidney, or liver events. CVD: Cardiovascular disease; CKD: Chronic kidney disease; FIB-4: Fibrosis-4; MARD: Mild age-related dysmetabolism; MOD: Mild obesity-related dysmetabolism; SID: Severe insulin deficiency; SIR: Severe insulin resistance.