Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients

doi:10.4239/wjd.125355

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World Journal of Diabetes

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1948-9358

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Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Oct 15, 2026; 17(10): 125355
Published online Oct 15, 2026. doi: 10.4239/wjd.125355

Table 5 Comparison of baseline clinical characteristics stratified by gender, n (%)/mean ± SD

Variables	Male			Female
Variables	Non-MASLD (n = 206)	MASLD (n = 169)	P value	Non-MASLD (n = 174)	MASLD (n = 99)	P value
Age (year)	58.59 ± 12.31	49.11 ± 12.97	< 0.001	63.15 ± 10.65	57.63 ± 11.93	< 0.001
Duration (year)	6.00 (2.25, 15.00)	3.00 (1.00, 8.00)	< 0.001	10.00 (3.00, 17.00)	4.00 (2.00, 10.00)	< 0.001
SBP (mmHg)	137.60 ± 18.35	139.93 ± 14.87	0.174	141.48 ± 20.46	140.39 ± 20.16	0.673
DBP (mmHg)	83.88 ± 12.12	87.84 ± 11.20	0.001	77.10 ± 10.70	82.54 ± 13.42	< 0.001
BMI (kg/m²)	25.34 ± 3.86	28.67 ± 4.97	< 0.001	24.85 ± 3.63	27.55 ± 4.55	< 0.001
WC (cm)	95.80 ± 9.45	103.93 ± 11.79	< 0.001	90.43 ± 12.28	95.59 ± 10.96	< 0.001
HC (cm)	100.95 ± 8.14	107.25 ± 10.77	< 0.001	98.63 ± 9.70	102.79 ± 11.10	0.001
LDL-C (mmol/L)	2.96 ± 0.90	3.16 ± 0.93	0.038	3.11 ± 0.95	3.23 ± 1.01	0.299
HDL-C (mmol/L)	1.19 ± 0.28	1.15 ± 0.31	0.200	1.33 ± 0.29	1.24 ± 0.29	0.016
TG (mmol/L)	2.03 ± 2.68	3.12 ± 3.60	0.001	1.56 ± 1.66	2.09 ± 1.43	0.008
TC (mmol/L)	4.72 ± 1.28	5.18 ± 1.53	0.002	4.90 ± 1.31	5.15 ± 1.40	0.143
ALT (U/L)	20.00 (15.00, 27.00)	29.00 (21.00, 46.00)	< 0.001	18.00 (13.00, 29.00)	28.00 (18.50, 42.00)	< 0.001
AST (U/L)	17.00 (14.00, 21.00)	22.00 (17.00, 32.00)	< 0.001	18.00 (14.00, 23.00)	22.00 (16.00, 36.50)	< 0.001
FBG (mmol/L)	9.15 ± 3.33	9.92 ± 3.29	0.025	9.14 ± 3.73	9.28 ± 2.73	0.737
HbA1c (%)	8.60 ± 2.29	8.75 ± 1.86	0.488	8.55 ± 2.02	8.68 ± 1.95	0.605
BUN (mmol/L)	6.17 ± 2.17	5.69 ± 3.41	0.104	5.31 ± 1.87	5.33 ± 1.56	0.912
UA (mmol/L)	350.02 ± 97.94	386.92 ± 104.17	< 0.001	296.78 ± 84.93	325.13 ± 97.32	0.013
Scr (mmol/L)	71.85 ± 25.51	67.20 ± 13.64	0.033	58.05 ± 22.45	58.41 ± 32.85	0.913
Hcy (μmol/L)	14.96 ± 6.32	16.03 ± 8.10	0.153	12.30 ± 5.82	12.61 ± 9.22	0.737
RBC (× 10¹²/L)	4.80 ± 0.56	4.98 ± 0.51	0.001	4.28 ± 0.50	4.51 ± 0.40	< 0.001
Hb (g/L)	147.66 ± 16.79	154.50 ± 16.42	< 0.001	128.18 ± 16.78	134.32 ± 13.88	0.002
WBC (× 10⁹/L)	6.05 ± 1.63	6.57 ± 2.11	0.007	5.91 ± 1.77	6.39 ± 1.93	0.037
PLT (× 10⁹/L)	207.93 ± 54.88	229.49 ± 59.17	< 0.001	230.16 ± 60.66	240.97 ± 63.53	0.165
Smoking	-	-	0.782	-	-	1.000
No	109 (52.91)	87 (51.48)	-	171 (98.28)	98 (98.99)	-
Yes	97 (47.09)	82 (48.52)	-	3 (1.72)	1 (1.01)	-
HT	-	-	0.015	-	-	0.721
No	100 (48.54)	61 (36.09)	-	83 (47.70)	45 (45.45)	-
Yes	106 (51.46)	108 (63.91)	-	91 (52.30)	54 (54.55)	-
eGDR quantile	-	-	< 0.001	-	-	0.412
Q1	31 (15.05)	63 (37.28)	-	38 (21.84)	30 (30.30)	-
Q2	55 (26.70)	38 (22.49)	-	43 (24.71)	25 (25.25)	-
Q3	54 (26.21)	40 (23.67)	-	45 (25.86)	22 (22.22)	-
Q4	66 (32.04)	28 (16.57)	-	48 (27.59)	22 (22.22)	-

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; WC: Waist circumference; HC: Hip circumference; HbA1c: Glycated hemoglobin; BUN: Blood urea nitrogen; Scr: Serum creatinine; UA: Uric acid; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FBG: Fasting blood glucose; ALT: Alanine aminotransferase; AST: Aspartate transaminase; Hcy: Homocysteine; RBC: Red blood cell; WBC: White blood cell; Hb: Hemoglobin; PLT: Platelet; HT: Hypertension; eGDR: Estimated glucose disposal rate; MASLD: Metabolic dysfunction-associated steatotic liver disease.

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Citation: Yin JT, Lu YX, Li ZM, Niu S. Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients. World J Diabetes 2026; 17(10): 125355
URL: https://www.wjgnet.com/1948-9358/full/v17/i10/125355.htm
DOI: https://dx.doi.org/10.4239/wjd.125355

Yin JT, Lu YX, Li ZM, Niu S. Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients. World J Diabetes 2026; 17(10): 125355 [DOI: 10.4239/wjd.125355]

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