Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients

doi:10.4239/wjd.125355

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World Journal of Diabetes

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1948-9358

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World J Diabetes. Oct 15, 2026; 17(10): 125355
Published online Oct 15, 2026. doi: 10.4239/wjd.125355

Table 2 Participants demographics and baseline characteristics based on estimated glucose disposal rate quartiles, n (%)/mean ± SD

Variables	eGDR				P value
Variables	Q1 (n = 162)	Q2 (n = 162)	Q3 (n = 162)	Q4 (n = 162)	P value
Age (year)	52.25 ± 15.49	58.86 ± 13.21	57.45 ± 11.48	60.21 ± 10.21	< 0.001
Duration (year)	4.00 (1.00, 10.00)	7.00 (2.00, 15.00)	5.50 (2.00, 13.00)	6.00 (2.00, 15.00)	0.037
SBP (mmHg)	150.88 ± 16.04	150.08 ± 16.30	132.93 ± 14.44	124.81 ± 11.46	< 0.001
DBP (mmHg)	90.60 ± 11.91	87.71 ± 11.35	79.20 ± 9.97	74.03 ± 8.23	< 0.001
BMI (kg/m²)	29.63 ± 5.28	25.94 ± 3.96	25.62 ± 3.61	24.47 ± 3.18	< 0.001
WC (cm)	106.49 ± 12.00	96.27 ± 8.17	94.59 ± 9.33	88.38 ± 11.20	< 0.001
HC (cm)	110.04 ± 11.10	101.49 ± 7.03	100.34 ± 8.57	97.11 ± 9.31	< 0.001
LDL-C (mmol/L)	3.38 ± 1.01	3.01 ± 0.92	3.05 ± 0.86	2.93 ± 0.92	< 0.001
HDL-C (mmol/L)	1.16 ± 0.27	1.25 ± 0.31	1.24 ± 0.31	1.26 ± 0.30	0.017
TG (mmol/L)	2.42 ± 1.95	2.24 ± 2.43	2.27 ± 3.15	1.87 ± 2.91	0.284
TC (mmol/L)	5.30 ± 1.46	4.92 ± 1.29	4.88 ± 1.38	4.71 ± 1.33	0.001
ALT (U/L)	32.50 (19.00, 47.75)	23.00 (16.00, 34.00)	21.00 (16.00, 29.75)	20.00 (14.00, 29.00)	< 0.001
AST (U/L)	23.00 (16.00, 36.00)	19.00 (15.25, 25.00)	18.00 (16.00, 23.00)	18.00 (16.00, 22.00)	< 0.001
FBG (mmol/L)	10.60 ± 3.48	9.31 ± 3.75	9.30 ± 3.08	8.27 ± 2.63	< 0.001
HbA1c (%)	9.95 ± 2.00	8.30 ± 1.90	8.81 ± 2.13	7.49 ± 1.30	< 0.001
BUN (mmol/L)	5.59 ± 3.20	6.01 ± 2.43	5.56 ± 2.31	5.59 ± 1.54	0.290
UA (mmol/L)	362.64 ± 107.67	344.64 ± 109.19	339.48 ± 98.40	319.43 ± 86.51	0.002
Scr (mmol/L)	65.30 ± 22.30	67.12 ± 27.16	64.83 ± 28.95	62.27 ± 16.73	0.348
Hcy (μmol/L)	15.53 ± 7.85	14.57 ± 8.32	13.17 ± 5.16	13.38 ± 7.48	0.012
RBC (× 10¹²/L)	4.87 ± 0.57	4.60 ± 0.60	4.66 ± 0.58	4.51 ± 0.49	< 0.001
Hb (g/L)	146.17 ± 18.78	141.71 ± 19.06	144.20 ± 20.91	136.62 ± 17.41	< 0.001
WBC (× 10⁹/L)	6.69 ± 2.04	6.38 ± 2.22	5.91 ± 1.46	5.82 ± 1.49	< 0.001
PLT (× 10⁹/L)	230.90 ± 67.82	224.08 ± 59.20	220.48 ± 57.95	222.81 ± 54.36	0.440
eGDR	2.83 ± 0.94	4.81 ± 0.39	6.69 ± 0.72	9.07 ± 1.14	< 0.001
Sex	-	-	-	-	< 0.001
Male	106 (65.43)	97 (59.88)	102 (62.96)	70 (43.21)	-
Female	56 (34.57)	65 (40.12)	60 (37.04)	92 (56.79)	-
Smoking	-	-	-	-	0.153
No	50 (30.86)	55 (33.95)	56 (34.57)	39 (24.07)	-
Yes	112 (69.14)	107 (66.05)	106 (65.43)	123 (75.93)	-
HT	-	-	-	-	< 0.001
No	7 (4.32)	14 (8.64)	110 (67.90)	158 (97.53)	-
Yes	155 (95.68)	148 (91.36)	52 (32.10)	4 (2.47)	-
MASLD	-	-	-	-	< 0.001
No	65 (40.12)	99 (61.11)	101 (62.35)	115 (70.99)	-
Yes	97 (59.88)	63 (38.89)	61 (37.65)	47 (29.01)	-

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; WC: Waist circumference; HC: Hip circumference; HbA1c: Glycated hemoglobin; BUN: Blood urea nitrogen; Scr: Serum creatinine; UA: Uric acid; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FBG: Fasting blood glucose; ALT: Alanine aminotransferase; AST: Aspartate transaminase; Hcy: Homocysteine; RBC: Red blood cell; WBC: White blood cell; Hb: Hemoglobin; PLT: Platelet; HT: Hypertension; eGDR: Estimated glucose disposal rate; MASLD: Metabolic dysfunction-associated steatotic liver disease.

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Citation: Yin JT, Lu YX, Li ZM, Niu S. Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients. World J Diabetes 2026; 17(10): 125355
URL: https://www.wjgnet.com/1948-9358/full/v17/i10/125355.htm
DOI: https://dx.doi.org/10.4239/wjd.125355

Yin JT, Lu YX, Li ZM, Niu S. Association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus patients. World J Diabetes 2026; 17(10): 125355 [DOI: 10.4239/wjd.125355]

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