Clinical significance of serum thrombospondin-4 for interventional restenosis in diabetes patients complicated by lower extremity arteriosclerosis obliterans

Table 1 Comparison of baseline features of the training and validation cohorts, n (%)/mean ± SD

Characteristic	Training cohort (n = 100)	Validation cohort (n = 43)	t/Z/χ2	P value
Male	62 (62.00)	28 (65.10)	0.125	0.723
Age (year)	70.28 ± 9.63	73.70 ± 10.42	-1.898	0.060
Diabetes duration (year)	10.00 (5.00, 15.00)	11.00 (8.00, 15.00)	-0.353	0.724
Coronary heart disease	27 (27.00)	9 (20.90)	0.588	0.443
Cerebral infarction	45 (45.00)	14 (32.60)	1.921	0.166
Smoking	43 (43.00)	22 (51.20)	0.808	0.369
Drinking	35 (35.00)	18 (41.90)	0.607	0.436
Fontaine stage			-0.356	0.722
II	39 (39.00)	13 (30.20)
III	23 (23.00)	15 (34.90)
IV	38 (38.00)	15 (34.90)
BMI (kg/m2)	23.12 ± 3.98	22.11 ± 3.40	1.465	0.145
Hb (g/L)	122.81 ± 21.83	125.79 ± 18.36	-0.784	0.435
ALB (g/L)	38.65 (36.43, 40.78)	39.00 (34.30, 40.70)	-0.704	0.481
ALT (U/L)	14.00 (11.25, 22.00)	14.00 (12.00, 19.00)	-0.659	0.510
AST (U/L)	16.00 (13.25, 21.75)	16.00 (12.00, 19.00)	-0.814	0.416
TBIL (μmol/L)	9.45 (7.13, 13.43)	8.92 (6.77, 12.28)	-1.054	0.292
Scr (μmol/L)	75.00 (60.25, 110.23)	75.00 (57.00, 91.00)	-0.920	0.357
FPG (μmol/L)	7.05 (5.87, 8.84)	6.58 (5.42, 8.31)	-1.072	0.284
HbA1c (%)	7.75 ± 1.59	7.36 ± 1.57	1.356	0.177
TC (mmol/L)	3.93 (3.09, 5.03)	3.66 (3.07, 5.06)	-0.396	0.692
TG (mmol/L)	1.31 (0.98, 1.68)	1.24 (0.97, 1.94)	-0.350	0.726
LDL-C (mmol/L)	2.57 ± 0.83	2.66 ± 0.85	-0.538	0.591
HDL-C (mmol/L)	0.96 ± 0.25	1.03 ± 0.29	-1.592	0.114
FIB (g/L)	4.04 (3.33, 5.24)	3.78 (2.94, 4.62)	-1.149	0.251
D-D (mg/L)	0.49 (0.29, 0.84)	0.43 (0.23, 0.70)	-1.231	0.218
hs-CRP (mg/L)	2.54 ± 1.25	2.29 ± 1.11	1.169	0.244
TSP-4 (ng/mL)	61.26 ± 29.46	64.47 ± 28.34	-0.605	0.546

Quantitative data are expressed as mean ± SD or median (IQR), analyzed using the t test or Mann-Whitney U test. Categorical data are expressed as n (%), analyzed using the χ² test or Mann-Whitney U test. BMI: Body mass index; Hb: Hemoglobin; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; Scr: Serum creatinine; FPG: Fasting plasma glucose; HbA1c: Glycated hemoglobin A1c; TC: Total cholesterol; TG: Triglycerides; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; FIB: Fibrinogen; D-D: D-dimer; hs-CRP: High-sensitivity C-reactive protein; TSP-4: Thrombospondin-4.