Associations of quantitative computed tomography measured abdominal and ectopic fat with impaired glucose metabolism in overweight/obese Chinese adults

doi:10.4239/wjd.123878

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Oct 15, 2026; 17(10): 123878
Published online Oct 15, 2026. doi: 10.4239/wjd.123878

Table 2 Baseline characteristics of the participants grouped by glucose metabolism status in both sexes, mean ± SD/median (interquartile range)

Variable	Men				Women
Variable	NGT (n = 39)	IGT (n = 26)	DM (n = 35)	ANOVA/Kruskal-Wallis test (P value)	NGT (n = 54)	IGT (n = 27)	DM (n = 24)	ANOVA/Kruskal-Wallis test (P value)
Age (years)	28.95 ± 8.94	32.46 ± 9.16	37.17 ± 8.43^b	< 0.001	29.56 ± 7.89	33.37 ± 6.46^a	30.46 ± 9.57	0.130
BMI	35.34 ± 4.60	34.80 ± 4.41	33.32 ± 6.30	0.252	32.26 ± 4.19	34.69 ± 4.85^a	33.19 ± 4.82	0.080
FPG (mmol/L)	5.10 (4.85-5.36)	5.99 (5.60-6.37)^b	7.61 (6.69-8.87)^b^,^d	< 0.001	5.08 (4.87-5.38)	5.53 (5.14-5.91)^b	6.72 (5.04-7.46)^b	< 0.001
2hPG (mmol/L)	5.74 (5.27-7.13)	8.88 (8.04-10.16)^b	13.19 (12.06-17.09)^b^,^d	< 0.001	6.51 (6.06-7.19)	8.70 (8.30-9.23)^b	12.48 (11.96-15.50)^b	< 0.001
TC (mmol/L)	4.80 (4.30-5.49)	5.39 (4.74-5.78)	4.92 (4.44-5.64)	0.153	4.72 (4.31-5.51)	4.73 (4.33-5.84)	4.78 (4.15-5.25)	0.648
TG (mmol/L)	1.42 (1.16-2.07)	1.91 (1.61-2.87)	2.1 (1.56-3.61)^b	0.005	1.19 (0.93-1.59)	1.66 (1.28-2.19)^b	1.40 (1.11-2.25)	0.006
LDL-C (mmol/L)	3.08 (2.55-3.58)	3.23 (2.90-3.71)	2.94 (2.64-3.43)	0.205	2.82 (2.65-3.27)	2.88 (2.63-3.54)	3.05 (2.44-3.32)	0.765
HDL-C (mmol/L)	1.23 (1.07-1.35)	1.09 (1.00-1.34)	1.08 (0.88-1.20)^a	0.027	1.29 (1.04-1.46)	1.13 (0.94-1.22)	1.05 (0.94-1.13)^b	0.004
DI_early	8.98 (6.35-12.46)	2.97 (1.85-4.58)^b	0.73 (0.37-2.17)^b^,^d	< 0.001	8.73 (5.56-10.82)	5.01 (3.50-7.31)^a	1.63 (1.01-5.18)^b	< 0.001
HOMA-IR	5.82 (3.55-8.22)	7.46 (6.08-11.48)	9.29 (5.31-15.65)^a	0.010	4.40 (2.85-7.68)	6.03 (4.48-8.56)	6.98 (4.65-10.21)	0.038
Hypertension	6	7	14	0.059	7	7	7	0.172
Dyslipidemia	10	11^a	20^c	0.022	11	10	9	0.160

^aP < 0.05 vs normal glucose tolerance.

^bP < 0.01 vs normal glucose tolerance.

^cP < 0.05 vs impaired glucose tolerance.

^dP < 0.01 vs impaired glucose tolerance.

NGT: Normal glucose tolerance; IGT: Impaired glucose tolerance; DM: Diabetes mellitus; BMI: Body mass index; FPG: Fasting plasma glucose; 2hPG: 2-hour postprandial glucose; TC: Total cholesterol; TG: Triglyceride, HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; HOMA-IR: Homeostatic model assessment of IR; ANOVA: Analysis of variance.

Full Size Table

Citation: Ma XL, Liu Y, Li BH, Zhao HC, Sun YP, Han HL, Yu WJ, Lin H, Mu WN, Liu YT. Associations of quantitative computed tomography measured abdominal and ectopic fat with impaired glucose metabolism in overweight/obese Chinese adults. World J Diabetes 2026; 17(10): 123878
URL: https://www.wjgnet.com/1948-9358/full/v17/i10/123878.htm
DOI: https://dx.doi.org/10.4239/wjd.123878

Ma XL, Liu Y, Li BH, Zhao HC, Sun YP, Han HL, Yu WJ, Lin H, Mu WN, Liu YT. Associations of quantitative computed tomography measured abdominal and ectopic fat with impaired glucose metabolism in overweight/obese Chinese adults. World J Diabetes 2026; 17(10): 123878 [DOI: 10.4239/wjd.123878]

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