Combined effects of glycemic status and adiposity on cardiovascular risk in chronic kidney disease: A nationwide population-based study

Table 6 Multivariate cox analysis for incident cardiovascular outcome by level of waist circumference

Outcome	WC status (cm)	n	Events (n)	Duration, PY	IR, per 1000	Adjusted HR (95%CI)
						Model 1	Model 2	Model 3
CVD	< 80/< 75	445617	23223	3336354.36	6.96	0.64 (0.63-0.65)	0.91 (0.90-0.93)	0.96 (0.95-0.98)
	< 85/< 80	358075	25492	2672239.66	9.54	0.87 (0.86-0.89)	0.95 (0.94-0.97)	0.97 (0.96-0.99)
	< 90/< 85	378139	30709	2808044.85	10.94	1 (reference)	1 (reference)	1 (reference)
	< 95/< 90	273818	23991	2020208.22	11.88	1.09 (1.07-1.11)	1.04 (1.02-1.06)	1.02 (1.00-1.04)
	< 100/< 95	149269	13995	1093690.46	12.80	1.17 (1.15-1.20)	1.12 (1.10-1.14)	1.07 (1.05-1.09)
	≥ 100/≥ 95	109941	10423	796802.43	13.08	1.20 (1.18-1.23)	1.26 (1.23-1.29)	1.17 (1.15-1.20)
MI	< 80/< 75	445617	11098	3372362.79	3.29	0.64 (0.63-0.66)	0.90 (0.88-0.92)	0.95 (0.93-0.98)
	< 85/< 80	358075	12119	2713709.57	4.47	0.87 (0.85-0.89)	0.95 (0.92-0.97)	0.97 (0.94-0.99)
	< 90/< 85	378139	14642	2858902.81	5.12	1 (reference)	1 (reference)	1 (reference)
	< 95/< 90	273818	11379	2060078.54	5.52	1.08 (1.05-1.11)	1.04 (1.01-1.07)	1.02 (0.99-1.04)
	< 100/< 95	149269	6665	1116627.75	5.97	1.17 (1.14-1.20)	1.12 (1.09-1.16)	1.07 (1.04-1.11)
	≥ 100/≥ 95	109941	5030	813792.65	6.18	1.21 (1.18-1.25)	1.28 (1.23-1.32)	1.18 (1.15-1.22)
Stroke	< 80/< 75	445617	13666	3362891.68	4.06	0.64 (0.62-0.65)	0.93 (0.91-0.95)	0.98 (0.95-1.00)
	< 85/< 80	358075	15068	2703325.42	5.57	0.87 (0.85-0.89)	0.96 (0.94-0.98)	0.98 (0.96-1.00)
	< 90/< 85	378139	18173	2846368.13	6.39	1 (reference)	1 (reference)	1 (reference)
	< 95/< 90	273818	14340	2049514.23	7.00	1.10 (1.07-1.12)	1.05 (1.03-1.07)	1.03 (1.00-1.05)
	< 100/< 95	149269	8355	1110933.10	7.52	1.18 (1.15-1.21)	1.12 (1.09-1.15)	1.07 (1.05-1.10)
	≥ 100/≥ 95	109941	6160	809433.86	7.61	1.20 (1.16-1.23)	1.25 (1.22-1.29)	1.17 (1.13-1.20)
Death	< 80/< 75	445617	41741	3401800.39	12.27	0.88 (0.87-0.90)	1.35 (1.33-1.37)	1.36 (1.34-1.38)
	< 85/< 80	358075	36435	2748088.03	13.26	0.95 (0.94-0.97)	1.06 (1.05-1.08)	1.07 (1.06-1.09)
	< 90/< 85	378139	40422	2901383.41	13.93	1 (reference)	1 (reference)	1 (reference)
	< 95/< 90	273818	31625	2092744.55	15.11	1.09 (1.07-1.10)	1.02 (1.01-1.04)	1.01 (1.00-1.03)
	< 100/< 95	149269	18297	1135942.79	16.11	1.16 (1.14-1.18)	1.08 (1.06-1.10)	1.05 (1.04-1.07)
	≥ 100/≥ 95	109941	14124	827875.1	17.06	1.24 (1.21-1.26)	1.30 (1.27-1.32)	1.24 (1.22-1.27)

Model 1: Non-adjusted; Model 2: Adjusted for age, sex; Model 3: Adjusted for model 2 plus smoking, alcohol drinking, regular exercise, income, hypertension, dyslipidemia. WC: Waist circumference; 95%CI: 95% confidence interval; CVD: Cardiovascular disease; MI: Myocardial infarction; PY: Person years; IR: Incidence rate; HR: Hazard ratio.