Combined effects of glycemic status and adiposity on cardiovascular risk in chronic kidney disease: A nationwide population-based study

Table 5 Multivariate cox analysis for incident cardiovascular outcome by level of body mass index

Outcome	BMI status (kg/m2)	n	Events (n)	Duration, PY	IR, per 1000	Adjusted HR (95%CI)
						Model 1	Model 2	Model 3
CVD	< 18.5	56566	3383	397648.60	8.51	0.91 (0.88-0.94)	1.10 (1.07-1.14)	1.12 (1.08-1.16)
	< 23	535450	37165	3947307.38	9.42	1 (reference)	1 (reference)	1 (reference)
	< 25	410244	31995	3058693.76	10.46	1.11 (1.09-1.13)	0.99 (0.97-1.00)	0.97 (0.96-0.98)
	< 30	602426	47427	4504619.24	10.53	1.12 (1.10-1.13)	1.03 (1.02-1.04)	0.98 (0.96-0.99)
	≥ 30	110173	7863	819070.98	9.60	1.02 (1.00-1.05)	1.25 (1.22-1.28)	1.11 (1.08-1.14)
MI	< 18.5	56566	1682	401800.32	4.19	0.96 (0.92-1.01)	1.18 (1.12-1.24)	1.20 (1.14-1.26)
	< 23	535450	17569	4005904.07	4.39	1 (reference)	1 (reference)	1 (reference)
	< 25	410244	14925	3112148.57	4.80	1.09 (1.07-1.12)	0.97 (0.95-0.99)	0.95 (0.93-0.97)
	< 30	602426	22864	4583820.63	4.99	1.13 (1.11-1.16)	1.04 (1.02-1.06)	0.98 (0.96-1.00)
	≥ 30	110173	3893	831800.52	4.68	1.07 (1.03-1.11)	1.27 (1.23-1.32)	1.12 (1.08-1.16)
Stroke	< 18.5	56566	1928	401035.13	4.81	0.87 (0.83-0.91)	1.04 (0.99-1.09)	1.05 (1.00-1.10)
	< 23	535450	22294	3988702.59	5.59	1 (reference)	1 (reference)	1 (reference)
	< 25	410244	19280	3097139.88	6.23	1.11 (1.09-1.13)	1.00 (0.98-1.01)	0.98 (0.96-1.00)
	< 30	602426	27770	4565772.03	6.08	1.09 (1.07-1.11)	1.01 (0.99-1.03)	0.96 (0.94-0.98)
	≥ 30	110173	4490	829816.79	5.41	0.97 (0.94-1.00)	1.22 (1.18-1.26)	1.09 (1.05-1.12)
Death	< 18.5	56566	10755	405566.28	26.52	1.65 (1.62-1.68)	1.86 (1.82-1.90)	1.83 (1.79-1.87)
	< 23	535450	66001	4052235.98	16.29	1 (reference)	1 (reference)	1 (reference)
	< 25	410244	42492	3154949.89	13.47	0.82 (0.81-0.83)	0.75 (0.74-0.76)	0.76 (0.75-0.77)
	< 30	602426	54969	4651464.79	11.82	0.72 (0.71-0.73)	0.71 (0.71-0.72)	0.70 (0.70-0.71)
	≥ 30	110173	8427	843617.33	9.99	0.62 (0.60-0.63)	0.92 (0.90-0.94)	0.87 (0.85-0.89)

Model 1: Non-adjusted; Model 2: Adjusted for age, sex; Model 3: Adjusted for model 2 plus smoking, alcohol drinking, regular exercise, income, hypertension, dyslipidemia. BMI: Body mass index; 95%CI: 95% confidence interval; CVD: Cardiovascular disease; MI: Myocardial infarction; PY: Person years; IR: Incidence rate; HR: Hazard ratio.