Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy

doi:10.4239/wjd.v17.i1.112027

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2026; 17(1): 112027
Published online Jan 15, 2026. doi: 10.4239/wjd.v17.i1.112027

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Figure 7 Impact of microtubule affinity-regulating kinase 4 knockdown on mitophagy was counteracted by UNC-51-like kinase 1 knockdown. A-G: Western blotting quantification of microtubule affinity-regulating kinase 4, UNC-51-like kinase 1, p62, Parkin, Beclin1, and microtubule-associated protein 1 light chain 3B proteins. Values are mean ± SD (n = 4). ^aP < 0.05, and ^bP < 0.01. Sh: Small hairpin; NC: Negative control; HG: High glucose; MARK4: Microtubule affinity-regulating kinase 4; ULK1: UNC-51-like kinase 1; LC3B: Microtubule-associated protein 1 light chain 3B; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; NS: Not significance.

Citation: Wu Y, Wang WY, Zhang JQ, Wang S, Zeng Z, Fu L, Li B. Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy. World J Diabetes 2026; 17(1): 112027
URL: https://www.wjgnet.com/1948-9358/full/v17/i1/112027.htm
DOI: https://dx.doi.org/10.4239/wjd.v17.i1.112027

Wu Y, Wang WY, Zhang JQ, Wang S, Zeng Z, Fu L, Li B. Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy. World J Diabetes 2026; 17(1): 112027 [PMID: 41608103 DOI: 10.4239/wjd.v17.i1.112027]

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