Targeting Ras homolog enriched in brain 1 to restore β-cell mass and function: A potential therapeutic strategy for diabetes

Figure 2 A schematic diagram showing Ras homolog enriched in brain 1-high-expression-mediated β-cell proliferation/function enhancement via dual pathway activation and hepatocyte nuclear factor 4 alpha upregulation, with translational research pipeline. Rheb1: Ras homolog enriched in brain 1; mTORC1: Mechanistic target of rapamycin complex 1; AMPK: AMP-activated protein kinase; HNF4α: Hepatocyte nuclear factor 4 alpha.