Postprandial C-peptide is more relevant to hemoglobin A1c levels and diabetic microvascular complications than fasting C-peptide in type 2 diabetes

Table 4 Logistic regression of diabetic peri-neuropathy

	Model 1		Model 2		Model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
FCP	0.999 (0.998-1)	0.008	0.999 (0.998-1)	0.239	1 (0.999-1.001)	0.421
2hCP	1 (0.999-1)	0.001	1 (0.999-1)	0.008	1 (0.999-1)	0.046
Delta CP	0.999 (0.999-1)	0.003	0.999 (0.999-1)	0.007	1 (0.999-1)	0.042
CP ratio	0.994 (0.984-1.005)	0.294	0.994 (0.981-1.006)	0.324	0.994 (0.982-1.007)	0.372
FCP/fasting plasma glucose	0.989 (0.984-0.995)	0	0.992 (0.986-0.998)	0.009	0.993 (0.986-1)	0.042
2hCP/postprandial blood glucose	0.995 (0.992-0.998)	0.001	0.996 (0.993-0.999)	0.01	0.996 (0.993-1)	0.067
Delta CP/BG	0.996 (0.991-1)	0.035	0.996 (0.992-1)	0.077	0.997 (0.992-1.002)	0.298
CP/BG ratio	0.984 (0.948-1.022)	0.404	0.982 (0.932-1.036)	0.508	0.985 (0.943-1.029)	0.494

BG: Blood glucose; CP: C-peptide; FCP: Fasting C-peptide; Model 1: Unadjusted; Model 2: Adjusted for age, duration and alanine transaminase; Model 3: Adjusted for model 2 plus hemoglobin A1c; OR: Odds ratio; 2hCP: 2 hours postprandial C-peptide.