Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia

Figure 4 Receiver operating characteristic curves on the left, showing the performance of each marker in distinguishing between prediabetic individuals with diabetic retinopathy (green columns) and those without (red columns). A: T-cell immunoglobulin and mucin domain 3/HAVCR2; B: Galectin-3; C: Tumor necrosis factor receptor 1; D: Tumor necrosis factor receptor 2 with the area under the curve values. Box plots on the right, displaying the distribution of values for each marker across different groups [diabetic retinopathy (RTD) vs non-RTD] with the red line showing the optimal cut-off value for each of them. TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; GAL-3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1; RTD: Diabetic retinopathy.