Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia

Figure 3 Receiver operating characteristic analysis. A: Interleukin 6; B: T-cell immunoglobulin and mucin domain 3/HAVCR2; C: Tumor necrosis factor receptor 2; D: Galectin-3. As biomarkers of hypofiltration-3, displaying their performance in distinguishing between prediabetic individuals with estimated glomerular filtration rate (eGFR) < 60 (G3a) and those with eGFR > 60 (G1/G2). The area under the curve values and optimal cut-off points for each biomarker are clearly indicated. TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; GAL-3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1.