Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia

Figure 1 Receiver operating characteristic analysis for predicting biomarkers of hyperfiltration. A: Interleukin 6; B: T-cell immunoglobulin and mucin domain 3/HAVCR2; C: Tumor necrosis factor receptor 2; D: Galectin-3. Left panels show receiver operating characteristic curves of each marker in distinguishing between estimated glomerular filtration rate (eGFR) > 130. The area under the curve values are provided, indicating the overall predictive power of each marker. Right panels: Box plots display the distribution of values for each marker across different groups [eGFR > 130 (heart failure, green columns) and control individuals (G1/G2, red columns)], with the red line indicating the optimal cut-off value. IL-6: Interleukin-6; TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; GAL-3: Galectin-3; HF: Heart failure.