Metabolic score for insulin resistance is associated with adverse cardiovascular events in patients with type 2 diabetes

Table 3 Additional predictive value of metabolic score for insulin resistance for outcome

Outcome	C-statistic (95%CI)	P value	NRI (95%CI)	P value	IDI (95%CI)	P value
MACEs
Conventional model	0.669 (0.660-0.679)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.674 (0.664-0.683)	0.0170	0.054 (0.019-0.084)	0.0070	0.003 (0.001-0.005)	< 0.0001
CVD mortality
Conventional model	0.706 (0.697-0.715)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.716 (0.708-0.725)	0.0050	0.104 (0.047-0.145)	< 0.0001	0.004 (0.002-0.008)	< 0.0001
Non-fatal MI
Conventional model	0.661 (0.652-0.670)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.663 (0.654-0.672)	0.2705	0.025 (-0.018 to 0.067)	0.1930	0.001 (0.000-0.003)	0.0130
Non-fatal stroke
Conventional model	0.632 (0.623-0.642)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.634 (0.624-0.643)	0.6054	0.052 (-0.015 to 0.102)	0.1660	0.001 (0.000-0.002)	0.0860
Total mortality
Conventional model	0.693 (0.684-0.702)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.701 (0.692-0.710)	0.0001	0.078 (0.048-0.108)	< 0.0001	0.004 (0.002-0.007)	< 0.0001
Congestive heart failure
Conventional model	0.707 (0.698-0.716)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.732 (0.723-0.741)	< 0.0001	0.211 (0.149-0.254)	< 0.0001	0.016 (0.009-0.025)	< 0.0001
Major CHD
Conventional model	0.677 (0.668-0.686)	-	Reference	-	Reference	-
Conventional model + METS-IR	0.684 (0.674-0.693)	0.0018	0.055 (0.024-0.081)	< 0.0001	0.004 (0.002-0.006)	< 0.0001

The conventional model was adjusted for age, sex, race, cardiovascular disease history, duration of diabetes, systolic blood pressure, diastolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, smoke, statin, aspirin. CI: Confidence interval; NRI: Net reclassification index; DI: Integrated discrimination improvement; CVD: Cardiovascular disease; IMACEs: Major adverse cardiovascular events; MI: Myocardial infarction; METS-IR: Metabolic score for insulin resistance.