Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637

Figure 11  Troxrutin improved the expression of transient receptor potential melastatin 7/calcineurin/p-dynamin-related protein 1^ser637 in high-concentration glucose-induced hippocampal neuronal cells. A: The normalized mRNA expression of transient receptor potential melastatin 7 (TRPM7) and calcineurin (CaN); B: Protein bands of TRPM7, CaN, and p-Drp1^ser637; C: The relative protein expression of TRPM7, CaN, and p-Drp1^ser637. After overexpression of TRPM7, the above effects of troxrutin were weakened. ^aP < 0.05, compared with normal control group; ^bP < 0.05, compared with high-concentration glucose group; ^cP < 0.05, compared with high-concentration glucose + troxerutin group. Data presented as mean ± SEM. TRPM7: Transient receptor potential melastatin 7; Drp1: Dynamin-related protein 1; CaN: Calcineurin; NC: Normal control; HG: Hypertonic group; T: Troxerutin.