Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637

Figure 5 The expression of calcineurin was upregulated and the expression of p- dynamin-related protein 1^ser637was downregulated in hippocampus of diabetic cognitive dysfunction mice. A: The normalized mRNA expression of calcineurin (CaN); B: Protein bands of CaN, T-dynamin-related protein 1 (Drp1), and p-Drp1^ser637; C: The relative protein expression of CaN, T-Drp1, and p-Drp1^ser637; D: Immunofluorescent staining of CaN; E: Immunofluorescent staining of p-Drp1^ser637. ^aP < 0.05, compared with dm group. Data presented as mean ± SEM. Drp1: Dynamin-related protein 1; dm: Control group; db: Diabetes group; CaN: Calcineurin; DAPI: 4’,6-diamidino-2-phenylindole.