Troxerutin improves diabetic cognitive dysfunction by inhibiting mitochondrial fission mediated by transient receptor potential melastatin 7/calcineurin/dynamin-related protein 1ser637

Figure 2 The db/db mice exhibit cognitive dysfunction at 17 weeks of age. A: The body weight (n = 8 mice per group); B: The fasting glucose level (n = 8 mice per group); the animals’ cognitive functions were assessed by the Morris water-maze test, novel object recognition and Nesting test as described in “materials and methods” (n = 8 mice per group); C: Escape latency (s); D: The times of crossing platform within 60 seconds in spatial probe test; E: Relative identification index; F: The scores of nesting; G: Swimming trajectories of the mice in exploration experiment. ^aP < 0.05, compared with dm group; ^bP < 0.05, compared with db group; ^cP < 0.05, compared with the db-T group. Data presented as mean ± SEM. dm: Control group; dm-T: Control + troxerutin group; db: Diabetes group; db-T: Diabetes + troxerutin group; db-T-B: Diabetes + troxerutin + bradykinin group.