Higher glycated hemoglobin amplifies the effect of apolipoprotein E epsilon 4-related cognition and olfaction impairments in type 2 diabetes

Table 5 Association of apolipoprotein E epsilon 4 with cognitive and olfactory function analyzed by stratified regression

Subgroup	Patients	Variable	P value	CI OR (95%CI)	P value	OD OR (95%CI)
High HbA1c group	386	APOE4	0.003	2.599 (1.374-4.914)	0.001	2.992 (1.550-5.774)
Low HbA1c group	250	APOE4	0.544	0.747 (0.291-1.916)	0.122	2.083 (0.821-5.281)

HbA1c: Glycated hemoglobin; CI: Cognitive impairment; OD: Olfactory dysfunction; OR: Odds ratio; CI: Confidence interval.