Higher glycated hemoglobin amplifies the effect of apolipoprotein E epsilon 4-related cognition and olfaction impairments in type 2 diabetes

Table 4 Association of glycated hemoglobin with cognitive and olfactory function analyzed by stratified regression

Subgroup	Patients	Variable	P value	CI OR (95%CI)	P value	OD OR (95%CI)
APOE4 carriers	85	HbA1c	< 0.001	2.830 (1.801-4.446)	0.013	1.479 (1.085-2.015)
Non-APOE4 carriers	551	HbA1c	0.150	1.081 (0.972-1.201)	0.136	1.095 (0.972-1.234)

APOE4: Apolipoprotein E epsilon 4; CI: Cognitive impairment; OD: Olfactory dysfunction; OR: Odds ratio; CI: Confidence interval.