Activation of farnesoid X receptor upregulates binding immunoglobulin protein expression and alleviates diabetic nephropathy

Figure 6 Downregulation of farnesoid X receptor expression in diabetic nephropathy mouse kidney tissue, changes in serum biochemical indicators of mice after farnesoid X receptor agonist intervention. A: Immunohistochemical staining detection of farnesoid X receptor expression in renal tissue of db/db mice at different weeks of age compared to db/m; B: Changes in blood creatinine levels in db/m and db/db mice at different weeks of age; C-E: Changes in urinary and serum biochemical indicators in db/db mice treated with obeticholic acid. NC: Negative control; INT-747: Obeticholic acid; Scr: Serum creatinine; UACR: Urine albumin-to-creatinine ratio; CR: Creatinine; BUN: Blood urea nitrogen.