Activation of farnesoid X receptor upregulates binding immunoglobulin protein expression and alleviates diabetic nephropathy

Figure 5 Farnesoid X receptor agonist upregulates binding immunoglobulin protein expression in db/db mice and improves renal fibrosis in diabetic nephropathy mice. A: Pathological changes in mouse kidneys after treatment with farnesoid X receptor (FXR) agonists and inhibitors; B: Immunohistochemical detection of the effects of FXR agonists and inhibitors on the expression of renal fibrosis related proteins. NC: Negative control; HE: Hematoxylin eosin; PAS: Periodic acid-Schiff stain; INT-747: Obeticholic acid; α-SMA: α-smooth muscle actin.