Activation of farnesoid X receptor upregulates binding immunoglobulin protein expression and alleviates diabetic nephropathy

Figure 4 The effect of artificial intervention on farnesoid X receptor activity on mesangial cell proliferation and extracellular matrix synthesis. A: Cell counting kit-8 detection of mesangial cell proliferation; B-E: Western blot detection of the expression of PCNA, fibronectin, α-smooth muscle actin, and collagen I. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ^dP < 0.0001. HG: High glucose; LG: Low glucose; INT-747: Obeticholic acid; Gugg: Guggulsterones; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; OD: Optical density; α-SMA: α-smooth muscle actin.