Identification and mechanistic insights of ubiquitin-proteasome system and pyroptosis-related biomarkers in type 2 diabetes mellitus

Figure 2 Identification and validation of four biomarkers. A: Differentially expressed genes (DEGs) were intersected with ubiquitin-proteasome system related genes (UPSGs) and pyroptosis-related genes (PRGs) to recognize differentially expressed UPSGs (DEUPSGs) and differentially expressed PRGs (DEPRGs), respectively; B: Correlation analysis of DEGs to DEPRGs and DEUPSGs; C: Receiver operating characteristic (ROC) curves of candidate genes obtained by correlation analysis; D and E: Expression analysis of biomarkers in the type 2 diabetes mellitus and normal control samples in the GSE76894 and GSE41762 datasets; F and G: ROC curves of four biomarkers in the GSE76894 and GSE41762 datasets; H: Correlation analysis of biomarkers. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001. AUC: Area under the curve.