Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study

Table 5 Multivariate cox analysis for incident end-stage renal disease according to exercise intensity

METs-min/week	Total (n)	ESRD (n)	Duration, PY	IR, 1000 PY	Adjusted HR (95% confidence interval)
					Model 1	Model 2	Model 3	Model 4
0	572290	6431	3234371	1.99	1 (Reference)	1 (Reference)	1 (Reference)	1 (Reference)
1-499	705215	6497	4056207	1.60	0.805 (0.778­0.833)	0.856 (0.827­0.886)	0.938 (0.906­0.971)	0.946 (0.913­0.979)
500-999	731798	6501	4215771	1.54	0.775 (0.749­ 0.802)	0.791 (0.764­0.819)	0.917 (0.886­ 0.950)	0.919 (0.888­0.952)
1000-1499	310973	2422	1804581	1.34	0.674 (0.643­ 0.706)	0.683 (0.652­0.716)	0.831 (0.793­0.871)	0.845 (0.806, 0.886)
≥ 1500	174755	1508	1010392	1.49	0.749 (0.709­0.793)	0.697 (0.658­0.737)	0.806 (0.762­0.853)	0.837 (0.791­0.886)

Model 1 is non-adjusted; Model 2 is adjusted for age and sex; Model 3 is adjusted model 2 plus income, smoking, drinking, regular exercise, hypertension, dyslipidemia, fasting glucose, oral hyperglycemic agent more than 3, estimated glomerular filtration rate; model 4 is adjusted for model 3 plus proteinuria. DM: Diabetes mellitus; ESRD: End-stage renal disease, PY: Person years; IR: Incidence rate; HR: Hazard ratio; MET: Metabolic equivalents of tasks.