Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis

Table 4 Generalized linear regression model for liver-related indicators and diabetes mellitus indicators

Model I1	HbA1c			Admission FPG			Discharge FPG
	B2	Wald χ2	P value	B2	Wald χ2	P value	B2	Wald χ2	P value
FIB-4	-0.006	0.002	0.967	0.001	4.056	0.044	-0.230	2.285	0.131
ALT	0.010	3.535	0.060	< 0	1.325	0.250	-0.005	1.160	0.281
AST	-0.015	3.762	0.052	> 0	0.238	0.626	0.017	4.807	0.028
ALP	-0.002	0.286	0.593	> 0	0.016	0.900	0.001	0.089	0.765
GGT	0.002	1.031	0.310	> 0	0.359	0.549	< 0	0.007	0.935
S/L	-0.049	0.019	0.889	-0.002	2.571	0.109	-0.229	0.299	0.584
TP	-10.462	0.924	0.336	-0.001	0.179	0.672	0.195	0.116	0.733
ALB	10.416	0.916	0.339	0.001	0.236	0.627	-0.254	0.153	0.696
Glo	10.511	0.933	0.334	0.001	0.144	0.704	-0.159	0.108	0.743
A/G	0.459	0.063	0.801	-0.003	0.196	0.658	0.773	0.115	0.735
TBIL	-0.012	1.157	0.282	< 0	0.516	0.473	0.003	0.118	0.731
Bc-Tr	0.021	0.913	0.339	> 0	1.423	0.233	-0.014	0.888	0.346
Fer	< 0	0.015	0.902	> 0	5.516	0.019	> 0	0.007	0.935
NEFA	0.908	2.279	0.131	> 0	0.348	0.556	-0.017	0.208	0.648
PIIIP	< 0	0.146	0.703	> 0	3.953	0.047	-0.002	3.208	0.073
CG	-0.001	0.011	0.916	< 0	2.509	0.113	-0.014	0.600	0.439
CIV	-0.001	1.301	0.254	< 0	0.345	0.557	0.001	0.644	0.422
LN	0.001	0.125	0.724	< 0	0.024	0.876	-0.003	0.894	0.344
HA	0.001	1.003	0.317	> 0	0.291	0.590	0.001	0.609	0.435
FBG	0.590	6.540	0.011	> 0	0.690	0.406	0.085	0.690	0.406
PT	-0.502	3.504	0.061	-0.002	3.454	0.063	0.563	4.491	0.034
Pa	-0.019	1.436	0.231	< 0	1.049	0.306	0.036	4.431	0.035
PT-INR	4.709	5.712	0.017	0.018	3.758	0.053	-4.251	3.306	0.069
APTT	-0.034	0.694	0.405	< 0	2.603	0.107	0.061	1.736	0.188
TT	0.096	0.641	0.423	> 0	0.361	0.548	0.104	0.766	0.381
LSM	-0.002	0.057	0.811	< 0	0.722	0.395	0.002	0.029	0.865
Model II3
FIB-4	-0.023	0.024	0.876	0.001	4.595	0.032	-0.250	2.437	0.119
ALT	0.009	2.597	0.107	< 0	3.959	0.047	-0.003	0.427	0.514
AST	-0.015	3.143	0.076	> 0	0.234	0.629	0.016	4.109	0.043
ALP	-0.002	0.326	0.568	< 0	0.025	0.873	0.002	0.334	0.563
GGT	0.001	0.894	0.344	> 0	0.379	0.538	> 0	0.005	0.945
S/L	-0.184	0.258	0.612	-0.003	4.536	0.033	-0.214	0.259	0.611
TP	-12.240	1.257	0.262	-0.002	1.045	0.307	0.025	0.001	0.969
ALB	12.243	1.258	0.262	0.002	1.093	0.296	-0.036	0.002	0.961
Glo	12.229	1.256	0.262	0.002	0.991	0.319	-0.046	0.007	0.933
A/G	-0.862	0.155	0.694	-0.008	1.071	0.301	0.078	0.001	0.976
TBIL	-0.007	0.342	0.559	< 0	0.138	0.711	< 0	0.000	0.994
Bc-Tr	0.012	0.273	0.602	> 0	0.864	0.353	-0.008	0.117	0.732
Fer	< 0	0.099	0.752	> 0	4.091	0.043	> 0	0.199	0.656
NEFA	0.986	2.448	0.118	> 0	0.397	0.529	-0.020	0.312	0.576
PIIIP	< 0	0.022	0.883	> 0	4.719	0.030	-0.002	3.487	0.062
CG	-0.003	0.035	0.851	< 0	3.592	0.058	-0.022	1.319	0.251
CIV	-0.001	1.120	0.290	< 0	0.742	0.389	0.002	1.585	0.208
LN	0.003	0.766	0.382	< 0	0.031	0.859	< 0	0.011	0.915
HA	> 0	0.144	0.704	< 0	0.015	0.902	0.002	1.954	0.162
FBG	0.618	6.920	0.009	> 0	0.650	0.420	0.121	1.407	0.236
PT	-0.513	3.180	0.075	-0.002	1.861	0.172	0.277	0.793	0.373
Pa	-0.018	1.107	0.293	< 0	0.346	0.556	0.021	1.234	0.267
PT-INR	4.871	5.484	0.019	0.018	3.213	0.073	-2.868	1.303	0.254
APTT	-0.041	0.880	0.348	< 0	4.926	0.026	0.077	2.621	0.105
TT	0.110	0.782	0.376	> 0	0.486	0.486	0.162	1.518	0.218
LSM	-0.002	0.026	0.871	< 0	0.400	0.527	0.002	0.028	0.866

¹Non-adjusted model.

²β > 0 indicates a positive correlation between the independent and dependent variables, while β < 0 indicates a negative correlation.

³Adjusted for age, sex, ethnicity, smoking history, alcohol consumption history and body mass index model.

HbA1c: Glycated hemoglobin A1c; FPG: Fasting plasma glucose; FIB-4: Fibrosis 4 score; ALT: Alanine aminotransferase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; S/L: Aspartate transaminase/alanine aminotransferase ratio; TP: Total protein; ALB: Albumin; Glo: Globulin; A/G: Albumin/globulin; TBIL: Total bilirubin; Bc-Tr: True conjugated bilirubin; Fer: Ferritin; NEFA: Nonestesterified fatty acid; PIIIP: Procollagen III peptide; CG: Cholyglycine; CIV: Collage type IV; LN: Laminin; HA: Hyaluronic acid; FBG: Fibrinogen; PT: Prothrombin time; Pa: Prothrombin activation; PT-INR: Prothrombin time-international normalized ratio; APTT: Activated partial thromboplastin time; TT: Thrombin time; LSM: Liver stiffness measurement.