Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis

Table 3 Comparison of liver-related characteristics of patients with different admission glycemic states

Variable	Good glucose control group	Normal blood glucose group	Poor glycemic control group	F/H/χ2	P value
TP (g/L)	67.44 ± 7.09	68.9 ± 7.47	67.35 ± 8.05	1.403	0.247
ALB (g/L)	37.31 ± 6.17	38.29 ± 6.25	36.28 ± 6.39	3.127	0.045
FIB-4	1.49 (0.7, 2.71)	1.12 (0.62, 2.48)	1 (0.52, 1.96)	0.534	0.766
ALT (U/L)	12 (10, 42)	23 (18.5, 50)	47.5 (29.75, 79)	1.098	0.577
AST (U/L)	29 (19, 39)	32 (23.5, 50.5)	43.5 (33, 64)	2.419	0.298
ALP (U/L)	108 (82, 130)	89 (71, 114.5)	104 (80, 149)	5.128	0.077
GGT (U/L)	65 (30, 97)	53 (26, 118)	66 (33, 121)	6.439	0.040
S/L	1.5 (0.9, 2.4)	1.2 (0.9, 1.55)	0.9 (0.7, 1.3)	5.337	0.069
Glo (g/L)	29.3 (25.5, 34.4)	29.2 (26.35, 33.05)	30.4 (27.2, 34.1)	0.910	0.635
A/G	1.29 (1.02, 1.47)	1.26 (1.02, 1.51)	1.23 (1.03, 1.5)	2.672	0.263
TBIL (μmol/L)	10.4 (7, 19.4)	14.5 (9.1, 28.35)	16.7 (10.53, 28.8)	0.740	0.691
Bc-Tr (μmol/L)	0.87 (0.38, 1.9)	1.52 (0.75, 3.28)	1.67 (0.95, 4.73)	2.249	0.325
Fer (ng/mL)	110 (29, 479.3)	196.5 (65.75, 415.75)	230.5 (119, 468.43)	5.556	0.062
NEFA (mmol/L)	0.59 (0.39, 0.7)	0.48 (0.3, 0.67)	0.54 (0.38, 0.72)	3.798	0.150
PIIIP (ng/mL)	61.8 (6.45, 142.33)	64.48 (13.1, 157.77)	52.9 (18.1, 146.41)	1.725	0.422
CG (μg/mL)	2.54 (1.39, 11.39)	4.47 (1.7, 21.19)	4.99 (1.83, 14.84)	1.692	0.429
CIV (ng/mL)	46.47 (29.1, 84.15)	53.12 (18.62, 115.61)	48.89 (22.64, 114.62)	0.844	0.656
LN (ng/mL)	79.15 (56.39, 152.71)	91.78 (61.28, 125.74)	86.91 (57.66, 123.61)	1.037	0.595
HA (ng/mL)	104.85 (81.46, 286.29)	117.28 (73.01, 264.51)	123.05 (73.25, 250.3)	2.197	0.333
FBG (g/L)	2.64 (1.9, 3.44)	2.32 (1.88, 2.76)	2.29 (1.83, 2.81)	0.817	0.665
PT (seconds)	13.1 (12.1, 15)	13.5 (12.6, 14.3)	13.4 (12.4, 14.7)	2.433	0.296
Pa (%)	79.1 (64.2, 97.2)	78 (67.4, 89.2)	80.3 (65.8, 91)	2.440	0.295
PT-INR	1.06 (1.02, 1.27)	1.12 (1.03, 1.24)	1.12 (1.05, 1.25)	3.747	0.154
APTT (seconds)	30 (26.8, 40.5)	30.1 (27.1, 34.3)	30.2 (27.3, 33.9)	0.339	0.844
TT (seconds)	17 (15.6, 18.3)	17.7 (16.7, 18.8)	17.7 (16.6, 19)	2.271	0.321
LSM (kPa)	5.3 (4.8, 5.6)	8.3 (7.35, 9.95)	23.35 (16.95, 36.2)	0.147	0.929

TP: Total protein; ALB: Albumin; FIB-4: Fibrosis 4 score; ALT: Alanine aminotransferase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; S/L: Aspartate transaminase/alanine aminotransferase ratio; Glo: Globulin; A/G: Albumin/globulin; TBIL: Total bilirubin; Bc-Tr: True conjugated bilirubin; Fer: Ferritin; NEFA: Nonestesterified fatty acid; PIIIP: Procollagen III peptide; CG: Cholyglycine; CIV: Collage type IV; LN: Laminin; HA: Hyaluronic acid; FBG: Fibrinogen; PT: Prothrombin time; Pa: Prothrombin activation; PT-INR: Prothrombin time-international normalized ratio; APTT: Activated partial thromboplastin time; TT: Thrombin time; LSM: Liver stiffness measurement.