Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes

doi:10.4239/wjd.v16.i7.106470

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World Journal of Diabetes

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World J Diabetes. Jul 15, 2025; 16(7): 106470
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.106470

Table 2 Differences in insulin dose among patients receiving multiple daily injection therapy and continuous subcutaneous insulin infusion therapy

Patients	Therapy	TDD	TDD/kg	TBa%
All patients, median (interquartile)	MDI therapy (n = 561)	30.00 (24.00, 38.00)	0.49 (0.38, 0.60)	43.00 (36.00, 50.00)
All patients, median (interquartile)	CSII therapy (n = 393)	26.40 (21.60, 32.40)^b	0.40 (0.32, 0.49)^b	42.00 (40.00, 50.00)^b
HbA1c < 8%, median (interquartile)	MDI therapy (n = 153)	25.00 (21.00, 29.00)	0.41 (0.33, 0.48)	44.40 (40.00, 49.00)
HbA1c < 8%, median (interquartile)	CSII therapy (n = 103)	21.60 (16.80, 27.00)^a	0.36 (0.29, 0.42)^a	40.00 (30.00, 50.00)^a
HbA1c ≥ 8%, median (interquartile)	MDI therapy (n = 408)	31.00 (26.00, 39.00)	0.51 (0.42, 0.62)	45.30 (36.40, 53.70)
HbA1c ≥ 8%, median (interquartile)	CSII therapy (n = 290)	27.20 (21.70, 33.00)^b	0.43 (0.34, 0.50)^b	44.40 (40.00, 50.00)

^aP < 0.05.

^bP < 0.01.

HbA1c: Glycated hemoglobin; CSII: Continuous subcutaneous insulin infusion; MDI: Multiple daily injection; TBa%: Ratio of total basal insulin dose to total daily insulin dose; TDD: Total daily insulin dose; TDD/kg: Total daily insulin dose per kilogram.

Citation: Sun RM, Dai DX, Xu F, Ling YL, Xie ZJ. Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes. World J Diabetes 2025; 16(7): 106470
URL: https://www.wjgnet.com/1948-9358/full/v16/i7/106470.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i7.106470