Efficacy of Xiaokeqing granules and lifestyle intervention in treating prediabetes mellitus considering metabolomic biomarkers: A randomised controlled trial

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Jul 15, 2025 (publication date) through Aug 16, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2025; 16(7): 105219
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.105219

Table 6 Metabolite and Kyoto Encyclopedia of Genes and Genomes pathways

Metabolite	KEGG pathway description
5-Hydroxy-L-Tryptophan	Tryptophan metabolism
L-Formyl kynurenine	Tryptophan metabolism, Biosynthesis of cofactors
2,3,4,5-tetrahydro-2-pyridinecarboxylic acid	Lysine degradation
N6-Acetyl-L-Lysine	Lysine degradation
Phenethylamine glucuronide	Biosynthesis of cofactors
3-Methyl-2-oxobutanoic acid	Pantothenate and CoA biosynthesis, Biosynthesis of cofactors
3-Methylindole	Tryptophan metabolism
4’-Phosphopantothenoylcysteine	Pantothenate and CoA biosynthesis, Biosynthesis of cofactors

KEGG: Kyoto Encyclopedia of Genes and Genomes; CoA: Certificate of analysis.

Citation: Zhao JD, Guo MZ, Zhang Y, Zhu SH, Wang YT, Zhang YP, Liu X, Cheng S, Wang F, Xu Q, Ruan NB, Fang ZH. Efficacy of Xiaokeqing granules and lifestyle intervention in treating prediabetes mellitus considering metabolomic biomarkers: A randomised controlled trial. World J Diabetes 2025; 16(7): 105219
URL: https://www.wjgnet.com/1948-9358/full/v16/i7/105219.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i7.105219