Altered hippocampal subfield volumes are associated with memory and executive function in patients with type 2 diabetes mellitus

doi:10.4239/wjd.v16.i7.104424

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World Journal of Diabetes

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World J Diabetes. Jul 15, 2025; 16(7): 104424
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.104424

Table 2 Between‐group differences in hippocampal subfield volume (mm³)

	T2DM (n = 55)	HC (n = 24)	t value	P value
Right Hippocampal tail	639.07 ± 63.17	697.02 ± 66.81	-3.501	0.001^a
Right subiculum	479.37 ± 42.52	497.18 ± 42.26	-1.7	0.930
Right CA1	704.05 ± 68.52	755.70 ± 69.03	-2.92	0.005^a
Right presubiculum	302.46 ± 29.19	311.54 ± 28.20	-1.281	0.204
Right molecular layer	615.83 ± 52.88	655.06 ± 49.74	-2.998	0.004^a
Right GC- DG	327.20 ± 34.45	337.69 ± 30.41	-1.282	0.204
Right CA3	251.50 ± 29.34	268.66 ± 24.81	-2.369	0.020
Right CA4	295.65 ± 31.64	293.96 ± 29.30	0.223	0.824
Right hippocampal fissure	181.26 ± 36.01	170.29 ± 32.34	1.284	0.203
Right parasubiculum	57.89 ± 11.68	56.75 ± 9.34	0.414	0.680
Right fimbria	75.57 ± 17.95	75.62 ± 14.86	-0.01	0.992
Right HATA	55.51 ± 8.67	61.91 ± 7.67	-3.053	0.003^a
Right whole hippocampus	3877.00 ± 375.91	3979.17 ± 336.49	-1.151	0.253
Left Hippocampal tail	600.08 ± 78.96	621.35 ± 96.56	-1.024	0.309
Left subiculum	483.49 ± 52.94	498.42 ± 47.40	-1.189	0.238
Left CA1	683.71 ± 79.23	693.66 ± 48.90	-0.537	0.593
Left presubiculum	321.94 ± 38.58	326.52 ± 33.88	-0.495	0.622
Left molecular layer	594.26 ± 56.83	612.20 ± 34.28	-1.351	0.181
Left GC-DG	315.88 ± 35.29	322.36 ± 18.73	-0.816	0.417
Left CA3	231.03 ± 34.77	231.77 ± 31.30	-0.09	0.928
Left CA4	274.92 ± 31.96	279.42 ± 19.50	-0.628	0.532
Left hippocampal fissure	171.75 ± 29.29	150.20 ± 19.06	3.167	0.002^a
Left parasubiculum	65.15 ± 11.56	60.78 ± 7.51	1.64	0.105
Left fimbria	85.12 ± 19.10	82.60 ± 19.55	0.538	0.592
Left HATA	57.35 ± 10.69	60.12 ± 8.06	-1.137	0.259
Left whole hippocampus	3748.20 ± 379.16	3786.32 ± 194.61	-0.439	0.662
eTIV	1562922.49 ± 153397.53	1567195.05 ± 120781.08	-0.279	0.781

^aP < 0.05 correction adjusted value had statistical significance.

Adjusted age, sex, education, duration and estimated total intracranial volume. T2DM: Type 2 diabetes mellitus; CA: Cornu ammonis; GC: Granular cell; DG: Dentate gyrus; HATA: Hippocampus amygdala transition area; eTIV: Estimated total intracranial volume.

Citation: Wu SX, Liang XL, Zhu QQ, Wang W, Jiang L, Chen HH, Tian S, Qi M. Altered hippocampal subfield volumes are associated with memory and executive function in patients with type 2 diabetes mellitus. World J Diabetes 2025; 16(7): 104424
URL: https://www.wjgnet.com/1948-9358/full/v16/i7/104424.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i7.104424