Longitudinal effects of Johnson & Johnson COVID-19 vaccination on metabolic biomarkers in type 2 diabetes mellitus in Ethiopia

Table 8 Generalized estimating equations multiple regression analysis for thromboxane

Variables (n = 224)		Crude effect		Adjusted effect
		β (95%CI)	P value	β (95%CI)	P value
Vaccination status	Vaccinated	-0.09 (-0.16, -0.01)	0.032a	-0.07 (-0.13, -0.01)	0.034b
	Unvaccinated	Reference		Reference
Time			< 0.001a		< 0.001b
	3 months	0.19 (0.19, 0.20)	< 0.001	0.19 (0.19, 0.20)	< 0.001b
	6 months	-0.19 (-0.20, -0.19)	< 0.001	-0.19 (-0.20, -0.19)	< 0.001b
	9 months	0.29 (0.29, 0.30)	< 0.001	0.29 (0.29, 0.30)	< 0.001b
	1 year	-0.19 (-0.20, -0.19)	< 0.001	-0.19 (-0.20, -0.19)	< 0.001b
	Baseline	Reference		Reference
Group timeb	Vaccinated 3 months			-0.00 (-0.01, 0.00)	0.247
	Vaccinated 6 months			0.01 (-0.01, 0.02)	0.247
	Vaccinated 9 months			-0.00 (-0.01, 0.00)	0.247
	Vaccinated 1 year			0.01 (-0.01, 0.02)	0.247
	Vaccinated baseline			Reference
Age group	≤ 40 years	-0.34 (-0.39, -0.28)	< 0.001a	-0.34 (-0.39, -0.29)	< 0.001b
	> 40 years	Reference		Reference
Sex	Female	-0.12 (-0.19, -0.04)	0.002a	-0.13 (-0.19, -0.07)	< 0.001b
	Male	Reference		Reference
Alcohol exposure	Yes	-0.02 (-0.11, 0.07)	0.706
	No	Reference
Chat exposure	Yes	-0.01 (-0.14, 0.12)	0.885
	No	Reference
Smoking exposure	Yes	-0.02 (-0.19, 0.16)	0.853
	No	Reference
Medications			< 0.001a		0.222
	Insulin	0.07 (-0.01, 0.16)	0.094	0.05 (-0.02, 0.12)	0.139
	Metformin	0.16 (0.08, 0.24)	< 0.001	0.05 (-0.02, 0.13)	0.151
	Both	Reference
Intercept				1.29

^aP ≤ 0.20.

^bP < 0.05

¹Biological criteria.

95%CI: 95% confidence interval.